Dual-modality in vivo imaging using rare-earth nanocrystals with near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence and magnetic resonance properties

Biomaterials
Jing ZhouFuyou Li

Abstract

Upconversion luminescence (UCL) imaging is expected to play a significant role in future photoluminescence imaging since it shows advantages of sharp emission lines, long lifetimes, superior photostability and no blinking. To further improve penetration depth, herein, near-infrared to near-infrared (NIR-to-NIR) UCL and magnetic properties were combined into a nanoparticle, and NIR-to-NIR UCL and MRI dual-modal bioimaging in vivo of whole-body animal were developed. Hydrophilic and carboxylic acid-functionalized Tm(3+)/Er(3+)/Yb(3+) co-doped NaGdF(4) upconversion nanophosphors (AA-NPs) were synthesized and showed both NIR-to-visible and NIR-to-NIR luminescence under excitation of 980 nm. Collecting the signal of the upconversion emission from AA-NPs in the visible and NIR range, all UCL imaging of cells, tissues and whole-body animals with different penetration depth showed high contrast. Moreover, AA-NPs showed a high relaxivity of 5.60 s(-1) (mM)(-1) and were successfully applied as contrast agents for magnetic resonance imaging (MRI) in vivo. By means of the combination of UCL imaging and MRI, the distribution of AA-NPs in living animals was studied, and the results indicated that these particles mainly accumulate in the live...Continue Reading

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Citations

Jun 19, 2012·Chemical Reviews·Yuming YangFuyou Li
Oct 1, 2011·Journal of the American Chemical Society·Qian LiuFuyou Li
Dec 8, 2011·Journal of the American Chemical Society·Qiang JuXueyuan Chen
Mar 1, 2012·Journal of the American Chemical Society·Qian LiuFuyou Li
Apr 18, 2012·Journal of the American Chemical Society·Xue TengLing Huang
Jun 15, 2013·Journal of the American Chemical Society·Yi LiuFuyou Li
Jan 15, 2013·ACS Nano·Uéslen RochaDaniel Jaque
May 21, 2010·The Analyst·Feng WangXiaogang Liu
Jun 26, 2010·Chemical Communications : Chem Comm·Qian LiuFuyou Li
Jun 10, 2011·Chemical Communications : Chem Comm·Ning LiuDan Zhao
Aug 14, 2012·Physical Chemistry Chemical Physics : PCCP·Wenlong XuGang Ho Lee
Sep 4, 2013·Physical Chemistry Chemical Physics : PCCP·Yan WangPiaoping Yang
Feb 11, 2014·International Journal of Nanomedicine·Jaehong Key, James F Leary
Jun 28, 2012·Sensors·Jiao Chen, Julia Xiaojun Zhao
Feb 6, 2013·Theranostics·Jyothi U MenonVikram D Kodibagkar
Jan 18, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Min LiuJun Lin
Mar 29, 2014·Inorganic Chemistry·Yunxin LiuYadong Li
May 6, 2014·Journal of Photochemistry and Photobiology. B, Biology·Yunyun Chen, Hong Liang
Jun 13, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dominik J NaczynskiPrabhas V Moghe
Jun 4, 2014·Analytica Chimica Acta·Matthew V DaCostaUlrich J Krull
Sep 15, 2012·Advanced Drug Delivery Reviews·Jutaek NamSungjee Kim
Feb 5, 2014·Advances in Colloid and Interface Science·Krishnendu ChatterjeeSantanu Paria

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