Abstract
Prostate cancer is the most common cancer for men in the western world. For the first time, a dual-modality probe, combining Raman spectroscopy and tactile resonance technology, has been used for assessment of fresh human prostate tissue. The study investigates the potential of the dual-modality probe by testing its ability to differentiate prostate tissue types ex vivo. Measurements on four prostates show that the tactile resonance modality was able to discriminate soft epithelial tissue and stiff stroma (p < 0.05). The Raman spectra exhibited a strong fluorescent background at the current experimental settings. However, stroma could be discerned from epithelia by integrating the value of the spectral background. Combining both parameters by a stepwise analysis resulted in 100% sensitivity and 91% specificity. Although no cancer tissue was analysed, the results are promising for further development of the instrument and method for discriminating prostate tissues and cancer.
References
Mar 21, 2000·Medical & Biological Engineering & Computing·A EklundO A Lindahl
Jul 27, 2000·Photochemistry and Photobiology·M G ShimB C Wilson
Oct 23, 2003·Analytical Chemistry·Paul H C Eilers
May 26, 2005·Urology·P CrowL-M WongKeeSong
Aug 16, 2005·Urology·S PhippsS A McNeill
Oct 19, 2005·Journal of Biomedical Optics·S KoljenovićG J Puppels
Dec 20, 2005·Urology·Toshiki TsuboiPeter T Scardino
Dec 1, 2006·Physiological Measurement·Ville JalkanenOlof A Lindahl
Jun 28, 2007·BJU International·Bob DjavanMichael Marberger
Oct 2, 2007·Physiological Measurement·Ville JalkanenOlof A Lindahl
Feb 9, 2008·Ultrasound in Medicine & Biology·Man ZhangKevin J Parker
Jun 19, 2008·Physiological Measurement·Ville JalkanenOlof A Lindahl
Oct 8, 2008·European Urology·Ofer YossepowitchFranceso Montorsi
Mar 24, 2009·Applied Optics·Yuichi KomachiHideo Tashiro
Apr 23, 2009·Journal of Medical Engineering & Technology·O A LindahlS Omata
Jul 5, 2011·Journal of Biomedical Optics·Xiaozhuo ShaoZhiwei Huang
Jul 6, 2012·Journal of Medical Engineering & Technology·S CandefjordO A Lindahl
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Apr 4, 2013·Journal of Medical Engineering & Technology·Anders P AstrandOlof A Lindahl
May 31, 2013·The Analyst·Morgan NybergOlof A Lindahl
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 25, 2014·Optics Letters·Chetan A PatilAnita Mahadevan-Jansen
Mar 13, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S Adamis, I M Varkarakis
Citations
Mar 10, 2016·Chemical Society Reviews·Oliver StevensNick Stone
Oct 27, 2017·Sensors·Anders P ÅstrandOlof A Lindahl
Mar 16, 2018·BJU International·Kelly AubertinDominique Trudel
Dec 21, 2018·Cancer Metastasis Reviews·Gregory W AunerMichelle A Brusatori
Feb 16, 2021·Biomedical Physics & Engineering Express·Olof Anton LindahlAnders Bergh