Dual-negative expression of Nrf2 and NQO1 predicts superior outcomes in patients with non-small cell lung cancer

Oncotarget
Ying-Hui TongNeng-Ming Lin

Abstract

Functional studies in non-small cell lung cancer (NSCLC) patients revealed that hyperactivation of the NF-E2-related factor 2 (Nrf2) pathway facilitates tumor growth. We examined the usefulness of Nrf2 and NQO1 as indicators of prognosis in NSCLC. Tumor and adjacent non-tumor tissue samples were collected from 215 NSCLC patients who had tumor resections between 2006 and 2011. Immunohistochemistry was performed to detect Nrf2 or NQO1 expression. The correlation between Nrf2 or NQO1 expression and survival outcomes was evaluated using the Kaplan-Meier method and Cox proportional hazards regression model. Levels of Nrf2 and NQO1 were elevated in tumor tissues. In particular, Nrf2 was elevated in nearly all tumor cells. NQO1 expression positively correlated with Nrf2 expression (P = 0.039). Nrf2 expression positively correlated with lymph node metastasis (P = 0.001) and negatively correlated with tumor differentiation (P = 0.032). As compared with either Nrf2 or NQO1 alone, dual-negative expression of Nrf2 and NQO1 was more predictive of superior overall survival (P = 0.020) and disease free survival (P = 0.037). Subgroup analyses showed that females, nonsmokers, and patients with advanced-stage NSCLC were suitable populations in w...Continue Reading

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Citations

Jun 14, 2018·The Clinical Respiratory Journal·Wei ChenLiang Yu
Aug 6, 2019·Oxidative Medicine and Cellular Longevity·Claudia RodriguesAna Cipak Gasparovic
Jan 7, 2021·Antioxidants & Redox Signaling·Emiliano Panieri, Luciano Saso
May 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad Reza SadeghiNasser Samadi
Aug 17, 2021·Dose-response : a Publication of International Hormesis Society·Shuai XuHong Zhang
Aug 28, 2021·Cells·Miriam Sánchez-OrtegaAntonio Garrido

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