Dual-organ invasion is associated with a lower survival rate than single-organ invasion distal bile duct cancer: A multicenter study

Scientific Reports
Kyueng-Whan MinHo Soon Choi

Abstract

The revised criteria of the 8th American Joint Committee on Cancer (AJCC) cancer staging system consider depth of invasion as one of the factors that determine stage in distal bile duct (DBD) cancer, but exclude adjacent organ invasion. The aims were to evaluate the association between adjacent organ invasion and relapse-free survival (RFS) and overall survival (OS) after curative surgical resection of DBD cancer and to propose optimal criteria for predicting clinical outcomes. In this retrospective cohort study, 378 patients with DBD cancer treated in multi-institutions between 1996 and 2013 were investigated. This study evaluated the relationship between clinicopathologic parameters and adjacent organ invasion and used organ invasion to compare the survival times of each group. Among 204 patients with adjacent organ invasion, 152 were in the single-organ invasion group and 52 were in the dual-organ invasion group based on a review of microscopic slides. In univariate and multivariate analyses, patients with dual-organ invasion had a shorter RFS and OS time than those with single-organ invasion. Organ invasion should be included as one of the factors that determine the AJCC stage; this might ultimately help to predict better t...Continue Reading

References

Oct 1, 1996·Annals of Surgery·A NakeebJ L Cameron
Sep 29, 2006·World Journal of Surgery·Yoshiaki MurakamiTaijiro Sueda
Feb 6, 2007·Journal of Surgical Oncology·Yoshiaki MurakamiTaijiro Sueda
Apr 26, 2007·Annals of Surgery·Michelle L DeOliveiraRichard D Schulick
Mar 13, 2010·Annals of Surgery·Kaori ItoWilliam R Jarnagin
Jan 23, 2015·The British Journal of Surgery·M KiriyamaUNKNOWN Nagoya Surgical Oncology Group

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Citations

Apr 1, 2020·Archives of Pathology & Laboratory Medicine·Xiaoyan Liao, Dongwei Zhang

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS
R

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