PMID: 7547478Jun 1, 1995Paper

Dual organisation of the Drosophila neuropeptide receptor NKD gene promoter

Mechanisms of Development
P RosayL Maroteaux

Abstract

Neuropeptide function in the peripheral and central nervous systems has been described in mammals as well as in insects. We previously reported the cloning of the neuropeptide receptor NKD, a Drosophila melanogaster homologue of the mammalian tachykinin receptors. This receptor is expressed during Drosophila embryonic development and in the adult fly. Use of the NKD promoter region to drive beta-galactosidase expression in transgenic flies reveals a bipartite promoter organisation: the distal region controls NKD expression in neurosecretory cells of the central nervous system during late embryogenesis, whereas the proximal region is responsible for transient expression in peripheral nervous system during late embryogenesis, whereas the proximal region is responsible for transient expression in peripheral nervous system precursor cells early in development. This early NKD expression, first restricted to the sensory organ precursor cell, an atonal positive cell, is abolished in the ato1 mutant. In addition, we show that the proneural protein atonal, in association with daughterless, transactivates the NKD promoter in Schneider S2 cells via the proximal E box NKDE2. Furthermore, heterodimers of atonal and daughterless interact wit...Continue Reading

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Citations

May 31, 2001·Genome Research·R S Hewes, P H Taghert
Oct 16, 2004·Molecular and Cellular Biology·Lynn M PowellAndrew P Jarman
Aug 7, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Lynn M PowellAndrew P Jarman
Aug 24, 2001·Developmental Biology·P B BushdidJ V Barnett
Aug 26, 2004·Developmental Biology·Pierre MattarCarol Schuurmans
Aug 7, 2002·The Journal of Biological Chemistry·Jonathan C RadfordJulian A T Dow
Nov 18, 2005·Molecular and Cellular Neurosciences·Asa M E WintherAlberto Ferrús

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