Dual PET/CT with (18)F-DOPA and (18)F-FDG in metastatic medullary thyroid carcinoma and rapidly increasing calcitonin levels: Comparison with conventional imaging

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
M C MarzolaDomenico Rubello

Abstract

To evaluate the role of a multi-imaging PET with (18)F-DOPA and (18)F-FDG in comparison with conventional imaging (CI) in recurrent medullary thyroid carcinoma (MTC). 18 MTC patients who had thyroidectomy were included; they presented with elevated and rapidly increasing calcitonin levels during follow up. CI had revealed metastatic deposits in 9 patients. Patients were referred to us for a PET/CT with (18)F-DOPA and (18)F-FDG. Histologic/cytologic confirmation of recurrent MTC was obtained in at least one PET-positive lesion in all patients. Foci of abnormal uptake were observed in 15 patients at (18)F-DOPA and in 11 at (18)F-FDG; 8 patients showed the same number of positive lesions with both tracers, 2 showed more lesions on (18)F-FDG, 1 was positive at (18)F-FDG alone and 5 at (18)F-DOPA alone. In 3 patients with a DOPA-positive loco-regional relapse a re-operation with curative intent was offered. SUV(max) values were higher for (18)F-FDG compared to (18)F-DOPA (mean 12.7+/-4.1 vs. 5.5+/-2.1, p<0.05). Calcitonin was higher in PET-positive patients compared to PET negative ones, while no significant differences were observed between (18)F-DOPA and (18)F-FDG positive patients. In MTC patients with rapidly increasing calciton...Continue Reading

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Citations

Jan 10, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Giorgio TregliaVittoria Rufini
Jan 6, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Domenico RubelloMilton D Gross
Feb 19, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Sona BalogovaFrançoise Montravers
Nov 16, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R Núñez Miller, M A Pozo
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Oct 17, 2013·Nuclear Medicine Communications·Sotirios ChondrogiannisDomenico Rubello
Nov 16, 2011·Nuclear Medicine Communications·Sotirios ChondrogiannisDomenico Rubello
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