Dual pH-Mediated Mechanized Hollow Zirconia Nanospheres

ACS Applied Materials & Interfaces
MingDong WangJiaJun Fu

Abstract

We demonstrate for the first time how to assemble mechanized hollow zirconia nanospheres (MHzNs), consisting of hollow mesoporous zirconia nanospheres (HMZNs) as nanoscaffolds and supramolecular switches anchored on the exterior surface of HMZNs. The remarkable advantage of substitution of HMZNs for conventional mesoporous silica nanoscaffolds is that HMZNs can suffer the hot alkaline reaction environment, which provides a novel strategy for functionalization and thus achieve dual pH-mediated controlled release functions by simple and practicable assembly procedure. Under neutral solution, cucurbituril[7] (CB[7]) macrocycles complexed with propanone bis(2-aminoethyl)ketal (PBAEK) to form [2]pseudorotaxanes as supramolecular switches, blocking the pore orifices and preventing the undesirable leakage of cargoes. When solution pH was adjusted to alkaline range, CB[7] macrocycles, acting as caps, disassociated from PBAEK stalks and opened the switches due to the dramatic decrease of ion-dipole interactions. While under acidic conditions, PBAEK stalks were broken on account of the cleavage of ketal groups, resulting in the collapse of supramolecular switches and subsequent release of encapsulated cargoes. MHzNs owning dual pH-mediat...Continue Reading

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Citations

Dec 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chendi DingJiajun Fu
Sep 4, 2018·Journal of Drug Targeting·Li LiDong-Gang Xu
Jan 5, 2021·Frontiers in Molecular Biosciences·Reju George ThomasYong Yeon Jeong
Feb 3, 2021·Angewandte Chemie·Hyuna JoKou Okuro
Jun 27, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Yunfei ChangQipeng Guo
Oct 22, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yunfei ChangYumei Gong

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