Dual-pharmacophore DNA-encoded chemical libraries

Current Opinion in Chemical Biology
Jörg Scheuermann, Dario Neri

Abstract

In contrast to single-pharmacophore DNA-encoded libraries, where only one chemical moiety is linked to DNA, dual-pharmacophore DNA-encoded chemical libraries feature the display of two independent small-molecules in close proximity. This, in principle, allows to explore adjacent epitopes on a pharmaceutical target of choice and hence the discovery of simultaneously binding pairs of fragments, by virtue of the chelate effect.

References

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Citations

Jan 29, 2016·ACS Chemical Biology·Hazem SalamonAndreas Brunschweiger
Nov 30, 2015·Current Opinion in Chemical Biology·Shelby K DoyleAngela N Koehler
Jan 10, 2017·Chembiochem : a European Journal of Chemical Biology·Gunther ZimmermannJörg Scheuermann
Dec 25, 2016·Bioorganic & Medicinal Chemistry Letters·Bingbing ShiXiaoyu Li
May 22, 2019·Expert Opinion on Drug Discovery·Guixian ZhaoXiaoyu Li
Dec 1, 2015·Chemical Science·Gang LiXiaoyu Li
Jul 17, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Oliver Seitz
Jun 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jie WangPhil S Baran
Oct 18, 2020·Metabolites·Andrea AngeliClaudiu T Supuran
Dec 23, 2015·Bioorganic & Medicinal Chemistry Letters·Sofia BarluengaNicolas Winssinger
Jul 4, 2021·Bioorganic & Medicinal Chemistry·Jean-Pierre DaguerNicolas Winssinger
Nov 4, 2021·Chemical Communications : Chem Comm·Sebastian OehlerJörg Scheuermann

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