Dual-phase CT of autoimmune pancreatitis: a multireader study

AJR. American Journal of Roentgenology
Naoki TakahashiSuresh T Chari

Abstract

The purpose of this study was to identify findings that aid in differentiating autoimmune pancreatitis from pancreatic carcinoma using dual-phase CT. Dual-phase CT scans of 74 patients (25 with autoimmune pancreatitis, 33 with pancreatic carcinoma, and 16 with a normal pancreas) were independently evaluated by three radiologists for enhancement of the pancreas; the presence of a capsule-like rim, peripancreatic strands, and pancreatic calcifications; pancreatic duct or bile duct changes; and renal involvement. The frequency of CT characteristics was compared between autoimmune pancreatitis and carcinoma. Interobserver agreement for the three reviewers for the assessment of CT characteristics was evaluated using kappa statistics. Diffusely decreased enhancement of the pancreas (autoimmune pancreatitis vs carcinoma: 28% vs 3%; p = 0.02, kappa = 0.33-0.75), capsule-like rim (40% vs 9%; p = 0.009, kappa = 0.42-0.66), peripancreatic strands (60% vs 27%; p = 0.02, kappa = 0.45-0.54), pancreatic calcifications (32% vs 9%; p = 0.04, kappa = 0.14-0.47), bile duct wall enhancement (52% vs 6%; p = 0.0001, kappa = 0.28-0.47), and renal involvement (28% vs 0%; p = 0.002, kappa = 0.32-0.74) were more frequent in patients with autoimmune panc...Continue Reading

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