Dual photoacoustic/ultrasound multi-parametric imaging from passion fruit-like nano-architectures

Nanomedicine : Nanotechnology, Biology, and Medicine
Paolo ArmanettiValerio Voliani

Abstract

Ultrasound (US) imaging is a well-established diagnostic technique to image soft tissues in real time, while photoacoustic (PA) is an emerging imaging technique employed to collect molecular information. Integration of PA and US imaging provides complementary information enhancing diagnostic accuracy without employing ionizing radiations. The development of contrast agents able to combine PA and US features is pivotal to improve the significance of PAUS imaging and for PAUS-guided treatment of neoplasms. Here, we demonstrate in relevant ex-vivo models that disassembling passion fruit-like nano-architectures (pfNAs) can be employed in PAUS imaging. pfNAs are composed by silica nanocapsules comprising aggregates of commercial NIR-dyes-modified polymers and ultrasmall gold nanoparticles. The intrinsic US and PA features of pfNAs have been fully characterized and validated in tissue-mimicking materials and in ex vivo preparations. Moreover, the application of a multi-parametric approach has allowed the increase of information extrapolated from collected images for a fine texture analysis.

Citations

Jun 30, 2019·International Journal of Molecular Sciences·Elisabetta FanizzaMarinella Striccoli
Oct 24, 2018·Frontiers in Bioengineering and Biotechnology·Ylea Vlamidis, Valerio Voliani
Nov 6, 2018·Nanomaterials·Filippo BegaraniValerio Voliani
Aug 1, 2020·Frontiers in Bioengineering and Biotechnology·Gennaro SanitàAnnalisa Lamberti
Aug 23, 2020·Nanomaterials·Giulia GiannoneValerio Voliani
Jan 15, 2021·European Journal of Medicinal Chemistry·Melissa SantiValerio Voliani
Apr 2, 2021·ACS Nano·Maria Laura Ermini, Valerio Voliani
Oct 16, 2020·Biomaterials Science·Fang ChenDavid Myung
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicolò MauroGennara Cavallaro
Jan 5, 2021·ACS Biomaterials Science & Engineering·Melissa SantiValerio Voliani
Aug 29, 2021·Pharmaceutics·Giorgia AilunoNunzio Denora

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