Dual pH/reduction-responsive hybrid polymeric micelles for targeted chemo-photothermal combination therapy

Acta Biomaterialia
Linhua ZhangDunwan Zhu

Abstract

The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs exhibited nano-sized structure (∼100 nm) with good monodispersity, high encapsulation efficiency of both ICG and DOX, triggered DOX release in response to acid pH and reduction environment, and excellent temperature conversion with laser irradiation. In vitro cellular uptake study indicated FA Co-PMs achieved significant targeting to BEL-7404 cells via folate receptor-mediated endocytosis, and laser-induced hyperthermia further enhanced drug accumulation into cancer cells. In vivo biodistribution study indicated that FA Co-PMs prolonged drug circulation and enhanced drug accumulation into the tumor via EPR effect and FA targeting. Furthermore, the ICG-based photo-triggered hyperthermia combined with DOX-based chemotherapy synergistically induced the BEL-7404 cell death and apoptosis, and efficie...Continue Reading

Citations

May 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Guangping YuShengsong Tang
Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali RazaHafiz M N Iqbal
Nov 28, 2020·Chemical Society Reviews·Cheng Xu, Kanyi Pu
Feb 5, 2021·ACS Biomaterials Science & Engineering·Pei-Yao XuAi-Zheng Chen
Apr 28, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jinlei PengHua Wei
Apr 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaskiran KaurKuppusamy Gowthamarajan
Jun 11, 2021·ACS Applied Materials & Interfaces·Xing-Qun PuLiang-Yin Chu
Jul 3, 2021·International Journal of Molecular Sciences·Banendu Sunder DashJyh-Ping Chen
Oct 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Raut BholakantJan Feijen

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