Dual projections of single orexin- or CART-immunoreactive, lateral hypothalamic neurons to the paraventricular thalamic nucleus and nucleus accumbens shell in the rat: Light microscopic study

Brain Research
Eun Y Lee, Hyun S Lee

Abstract

The paraventricular thalamic nucleus (PVT) is a major relay station to the limbic forebrain areas such as the nucleus accumbens shell (AcbSh). Both PVT and AcbSh are known to receive feeding/arousal-related peptidergic fibers including orexin (ORX) and cocaine- and amphetamine-regulated transcript (CART) peptide. In the first series of experiments, we examined the peptidergic fiber distribution in the AcbSh; the density of ORX (or CART) fibers in the AcbSh was substantially lower than that in the PVT. At the light microscopic level, ORX (or CART) terminals formed close appositions to choline acetyltransferase (ChAT)-, glutamate decarboxylase (GAD)-, or enkephalin (Enk)-immunoreactive neuronal elements in the AcbSh. In the second series of experiments, we addressed the question of whether single ORX (or CART) cells in the hypothalamus provided divergent axon collaterals to the PVT and AcbSh. ORX neurons with dual projections were found in the medial, central, and lateral subdivisions of the lateral hypothalamus (LH), which amounted to an average of 1.6% of total ORX cells. CART neurons with divergent axon collaterals were observed in the LH, zona incerta, dorsal hypothalamic area, and retrochiasmatic nucleus, which represented a...Continue Reading

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Citations

Jul 19, 2018·The Journal of Comparative Neurology·Manasi IyerMatthew E Carter
Mar 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Liching LoBrandon Weissbourd
Apr 27, 2020·Brain Research·Zhi Yi Ong, Gavan P McNally
Jul 10, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shani GendelisYonatan M Kupchik
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

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