Dual-purpose magnetic micelles for MRI and gene delivery.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Chunyan WangSubhra Mohapatra

Abstract

Gene therapy is a promising therapeutic approach for treating disease, but the efficient delivery of genes to desired locations with minimal side effects remains a challenge. In addition to gene therapy, it is also highly desirable to provide sensitive imaging information in patients for disease diagnosis, screening and post-therapy monitoring. Here, we report on the development of dual-purpose chitosan and polyethyleneimine (PEI) coated magnetic micelles (CP-mag-micelles) that can deliver nucleic acid-based therapeutic agents and also provide magnetic resonance imaging (MRI). These 'theranostic' CP-mag-micelles are composed of monodisperse hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) loaded into the cores of micelles that are self-assembled from a block copolymer of poly (D, L-lactide) (PLA) and monomethoxy polyethylene glycol (mPEG). For efficient loading and protection of the nucleic acids the micelles were coated with cationic polymers, such as chitosan and PEI. The morphology and size distribution of the CP-mag-micelles were characterized and their potential for use as an MRI-probe was tested using an MRI scanner. The T(2) relaxivity of mag-micelles was similar to CP-mag-micelles confirming that coating ...Continue Reading

References

Aug 2, 2001·Journal of the American Chemical Society·C M McIntoshV M Rotello
Jul 11, 2002·Journal of the American Chemical Society·Shouheng Sun, Hao Zeng
May 3, 2003·Nature Reviews. Genetics·Clare E ThomasMark A Kay
Aug 18, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xintao ShuaiJinming Gao
Jun 9, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·U LungwitzA Göpferich
Dec 22, 2005·Chembiochem : a European Journal of Chemical Biology·Lizeng GaoXiyun Yan
Feb 24, 2006·Chemical Biology & Drug Design·Gang HanVincent M Rotello
Feb 24, 2006·Annals of Biomedical Engineering·Daniel L J ThorekAndrew Tsourkas
Dec 15, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hu-Lin JiangChong-Su Cho
Aug 28, 2007·The Journal of Gene Medicine·Michael L EdelsteinJo Wixon
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Miriam BreunigAchim Goepferich
Oct 20, 2007·Nature Protocols·Olga MykhaylykChristian Plank
Apr 12, 2008·Journal of Biomedical Materials Research. Part a·Yu-Lun LouKam W Leong
Aug 19, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hu-Lin JiangChong-Su Cho
Jun 9, 2009·International Journal of Pharmaceutics·Dhananjay JereChong-Su Cho
Aug 28, 2009·Molecular Pharmaceutics·Jagadeesh Setti GuthiJinming Gao
Oct 5, 2010·Chemical Society Reviews·Leo Y T ChouWarren C W Chan
Feb 22, 2011·Biotechnology and Bioengineering·Chih-Hsiang ChangYun-Peng Chao
Mar 17, 2011·Biomaterials·Yi-An ChenTzong-Yueh Chen

❮ Previous
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Citations

Jun 27, 2013·International Journal of Pharmaceutical Investigation·Steffy B ManjilaJanardhanan Valsalakumari
Oct 1, 2013·Drug Delivery and Translational Research·Sandhya PranatharthiharanPadma V Devarajan
Dec 21, 2012·Expert Opinion on Drug Delivery·Soma Patnaik, Kailash C Gupta
Feb 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·M HowellS Mohapatra
Mar 24, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bo WuShi-Wen Huang
Mar 8, 2016·ACS Chemical Biology·Frederic GeinguenaudLaurence Motte
Nov 27, 2015·Nanomedicine·Randall A Meyer, Jordan J Green
Nov 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Benjamin NotteletJean Coudane
Oct 10, 2015·ACS Applied Materials & Interfaces·Sangram K SamalV Alek Dediu
Aug 15, 2013·Chemistry : a European Journal·Moom Sinn AwDusan Losic
Mar 4, 2015·ACS Applied Materials & Interfaces·Sangram K SamalV Alek Dediu
Jun 17, 2015·BioMed Research International·Saji UthamanIn-Kyu Park
Feb 4, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Mahasweta DasSubhra Mohapatra
May 3, 2014·Advanced Drug Delivery Reviews·Kevin M BennettIchio Aoki
May 6, 2014·Frontiers in Pharmacology·Aditi M Jhaveri, Vladimir P Torchilin
Dec 27, 2018·Bioscience, Biotechnology, and Biochemistry·Xiaowei SongGuangyu Jin
Jun 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Theodora Krasia-Christoforou, Theoni K Georgiou
Jun 3, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunyan WangSubhra Mohapatra
Mar 21, 2017·Cancer Chemotherapy and Pharmacology·Mahsa Yousefpour Marzbali, Ahmad Yari Khosroushahi
Jan 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yasemin YarHavva Yagci Acar
Jan 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongbo WangWenguang Liu
Sep 23, 2021·Journal of Biomaterials Science. Polymer Edition·Mohammad-Amin RahmatiMehraneh Kermanian

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