PMID: 2116980Jul 30, 1990Paper

Dual regulation by G proteins of agonist-dependent phosphorylation of muscarinic acetylcholine receptors

FEBS Letters
K Haga, T Haga

Abstract

Muscarinic acetylcholine receptors purified from porcine atrium were phosphorylated, depending on the presence of agonists, by a protein kinase partially purified from porcine brain, which had similar properties to the beta-adrenergic receptor kinase. GTP-binding regulatory proteins (Go) had dual effects on the phosphorylation of muscarinic receptors, i.e. stimulation at lower concentrations and inhibition at higher concentrations. The stimulatory effect was reproduced with the beta gamma subunit of Go and the inhibitory effect with the combination of the alpha and beta gamma subunits.

Citations

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