Dual-release formulation, a novel principle in L-dopa treatment of Parkinson's disease

Neurology
S DescombesO Rascol

Abstract

A single morning dose of dual-release formulation was compared with a slow-release formulation of L-dopa plus benserazide in a randomized, double-blind, cross-over study in 16 fluctuating patients with PD. The mean time to "on" was shorter with the dual-release formulation (43 +/- 31 minutes) than with the slow-release formulation (81 +/- 39 minutes) (p < 0.001), whereas the mean time to relapse to "off" was similar for both formulations. The dual-release formulation had a significantly shorter time to reach peak concentration (t(max)) and greater maximum concentration (C(max)) and area under the plasma concentration time curve (AUC(0--5 h)) than the slow-release formulation, whereas apparent elimination half-life (t(1/2)) was similar for both formulations.

References

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Citations

Nov 26, 2010·Journal of Neurology·Giovanni FabbriniAlfredo Berardelli
May 10, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kenneth C Waterman, Michael B Fergione
Nov 10, 2010·Clinical Neuropharmacology·Ulf KallweitClaudio L Bassetti
Feb 6, 2008·Expert Opinion on Drug Metabolism & Toxicology·Dag Nyholm, Hans Lennernäs
Jan 26, 2010·Expert Opinion on Drug Delivery·Ndidi NgwulukaDinesh Naidoo

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