Dual responsive copolymer micelles for drug controlled release

Journal of Colloid and Interface Science
Liang-Rong YangHui-Zhou Liu

Abstract

pH- and temperature-responsive polymeric drug carriers based on Chitosan oligosaccharide (CSO)-g-Pluronic copolymers were successfully synthesized for Doxorubicin (DOX) controlled release. The critical aggregation concentration of CSO-g-Pluronic is 0.035 mg/mL at 25 degrees C. The CSO-g-Pluronic and DOX-loaded CSO-g-Pluronic micelles have an average hydrodynamic diameter of 23.3 nm and 43.6 nm respectively at 30 degrees C and pH 7.0 with narrow size distribution. The temperature or pH responsive behavior of the micelles was characterized by dynamic light scattering, fluorescence spectroscopy, and zeta Potential Analysis. The temperature-dependent micellar transformation was induced by dehydration of Pluronic segments at higher temperature. The pH responsive volume increase was traced to the electrostatic repulsion between CSO segments from protonation of amino groups under acidic conditions. Consequently, the DOX release time was prolonged by CSO-g-Pluronic micelles at body temperature of 37 degrees C, and the DOX release was accelerated at mild acidic conditions (i.e. the pH environment around tumor tissues). The temperature- and pH-responsive properties of CSO-g-Pluronic copolymer have provided promising potentials for biomed...Continue Reading

References

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·A Bernkop-Schnürch, M E Krajicek
Jun 6, 2000·Advanced Drug Delivery Reviews·E S Ron, L E Bromberg
Mar 19, 2002·Advanced Drug Delivery Reviews·Vladimir P Torchilin
May 15, 2002·Biomacromolecules·Gisela BerthHelmuth Möhwald
Sep 3, 2002·Advanced Drug Delivery Reviews·Alexander V KabanovValery Yu Alakhov
Oct 26, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexandre MarinNatalya Y Rapoport
Jan 22, 2003·Advanced Drug Delivery Reviews·Alexander V KabanovDonald W Miller
Apr 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Narayan BhattaraiMiqin Zhang
Oct 24, 2006·Biomaterials·Ting-Fan YangHsing-Wen Sung
Nov 14, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hua WeiRen-Xi Zhuo
Nov 28, 2006·Advanced Drug Delivery Reviews·Dirk Schmaljohann
Feb 3, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Yuan TianKam C Tam
Jul 17, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y TianKam C Tam
Nov 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Shu ChenHui-Zhou Liu
Mar 4, 2008·Colloids and Surfaces. B, Biointerfaces·Kyung Min ParkKi Dong Park
Jun 11, 2008·Biomacromolecules·Ioannis A SogiasVitaliy V Khutoryanskiy
Jun 24, 2009·Biomacromolecules·Francisco M GoycooleaMaría J Alonso

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Citations

Jul 23, 2013·International Journal of Pharmaceutics·T T H PhamG Barratt
May 25, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Natalya Rapoport
Mar 10, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Minghui XuHongjie Wang
Apr 24, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xiaojuan WangJianbiao Ma
Oct 19, 2011·Macromolecular Bioscience·Mehrdad HamidiKobra Rostamizadeh
Dec 22, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Lianwei JiaHuizhou Liu
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Xiaozhen ZhanChangren Zhou

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