Dual responsive gelatin-based nanoparticles for enhanced 5-fluorouracil efficiency

Colloids and Surfaces. B, Biointerfaces
M Carmen MoránM Antònia Busquets

Abstract

The very slow progress in the therapeutic efficacy of the treatment of severe diseases has suggested the use of a growing need for a multidisciplinary approach to the delivery of therapeutics to targets tissues. There has been increasing effort in the design of stimuli-responsive nanomaterials that they will be developed into effective drug delivery vehicles. Most commonly, effective drug delivery is associated with nanomaterial-facilitated accumulation and/or cellular internalization. Recent studies in our lab have demonstrated that gelatin-based NPs can be considered suitable pH responsive devices for the effective intracellular delivery of drugs. Concerning cancer treatment, ligands recognizing tumour-associated antigens expressed on the surface of the tumour cells have been employed. Some of the target structures suitable for tumour targeting belong to integrins which mediate cell adhesion to extracellular matrix and other cells. Interestingly, gelatin chains contain motifs such as RGD sequences that can be recognised by integrins. In this work the inclusion of the anticancer drug 5-fluorouracil (5-FU) on these gelatin-based NPs has been projected. These NPs may provide an opportunity to increase the therapeutic effect usin...Continue Reading

Citations

Aug 11, 2019·Colloids and Surfaces. B, Biointerfaces·Mohaddeseh Mahmoudi Saber
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Kalpesh VaghasiyaRahul Kumar Verma
Nov 13, 2020·Biotechnology Advances·Amaia Huguet-CasqueroJose Luis Pedraz
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Albert Ferriol, Maria Del Carmen Morán
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tianjie ChenHong Liu

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