Dual role of dopamine D(2)-like receptors in the mediation of conditioned and unconditioned fear

FEBS Letters
Marcus L BrandãoTeddy Talbot

Abstract

A reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system, particularly the amygdala, clearly reduces conditioned fear. Similar D2 receptor antagonism in the neural substrates of fear in the midbrain tectum attenuates the processing of unconditioned aversive information. However, the implications of the interplay between opposing actions of dopamine in the rostral and caudal segments of the dopaminergic system are still unclear. Previous studies from this laboratory have reported the effects of dopaminergic drugs on behavior in rats in the elevated plus maze, auditory-evoked potentials (AEPs) recorded from the midbrain tectum, fear-potentiated startle, and conditioned freezing. These findings led to an interesting framework on the functional roles of dopamine in both anxiety and fear states. Dopamine D2 receptor inhibition in the terminal fields of the mesolimbic dopamine system generally causes anxiolytic-like effects, whereas the activity of midbrain substrates of unconditioned fear are enhanced by D2 receptor antagonists, suggesting that D2 receptor-mediated mechanisms play opposing roles in fear/anxiety processes, depending on the brain region under study. Dopamine appears to me...Continue Reading

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Citations

Aug 19, 2015·Psychiatry Research·Bariş O Yildirim, Jan J L Derksen
Sep 5, 2018·Reviews in the Neurosciences·Marcus L Brandão, Norberto C Coimbra
Nov 19, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Eva SnircovaGabriela Nosalova
Jan 12, 2019·Behavioural Pharmacology·Nayara C B BarrocaAmanda R de Oliveira
Jan 19, 2019·Psychopharmacology·Christine StubbendorffCarl W Stevenson
Nov 3, 2017·Frontiers in Neuroscience·Linda H KimPatrick J Whelan
Apr 23, 2021·Experimental Brain Research·Vivian M de VitaAmanda R de Oliveira

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