Dual role of hypoxia-inducible factor 1 α in experimental pulmonary tuberculosis: its implication as a new therapeutic target

Future Microbiology
Guillermina J Baay-GuzmanSara Huerta-Yepez

Abstract

Investigate the role of hypoxia-inducible factor-1α (HIF-1α) in pulmonary tuberculosis (TB). A model of progressive pulmonary TB in BALB/c mice, immunohistochemistry and digital pathology were used. High HIF-1α expression was observed during early TB in activated macrophages. During late TB, even higher HIF-1α expression was observed in foamy macrophages, which are resistant to apoptosis. Blocking HIF-1α during early infection with 2-methoxyestradiol worsened the disease, while during late TB, it induced macrophage apoptosis and decreased bacillary loads. HIF-1α has a dual role in experimental TB. This finding could have therapeutic implications because combined treatment with 2-methoxyestradiol and antibiotics appeared to eliminate mycobacteria more efficiently than conventional chemotherapy during advanced disease.

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Oct 13, 2001·Science·R K Bruick, S L McKnight
Feb 28, 2002·Biochemical and Biophysical Research Communications·Louis X LiuCanwen Jiang
Sep 6, 2002·Biochemical Pharmacology·Jean-Pascal PiretCarine Michiels
May 3, 2003·Cancer Cell·Nicola J MabjeeshParaskevi Giannakakou
Sep 4, 2003·The Journal of Experimental Medicine·Martin I VoskuilGary K Schoolnik
May 3, 2005·Nature Reviews. Drug Discovery·Mads Hald AndersenPer thor Straten
Sep 13, 2005·Biochemical and Biophysical Research Communications·William G Kaelin
Jan 20, 2006·European Journal of Immunology·Víctor Adolfo Ríos-BarreraRogelio Hernández-Pando
Sep 17, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S Huerta-YepezB Bonavida
Jul 31, 2009·Oncogene·T Ni Chonghaile, A Letai
Oct 21, 2009·The International Journal of Biochemistry & Cell Biology·Daniel P Gale, Patrick H Maxwell
Feb 9, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hong JiangQi Fang Li
Dec 27, 2011·The Journal of Infectious Diseases·Jamie HarperSanjay K Jain
May 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jeroen MaertzdorfStefan H E Kaufmann
Apr 12, 2014·PloS One·Estela Isabel BiniRogelio Hernández Pando
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·María A Duque-CorreaStephen T Reece
Apr 11, 2015·Clinical Science·Luciana BalboaRogelio Hernández-Pando
Jan 21, 2016·Tuberculosis·Jesus F Rangel-SantiagoSara Huerta-Yepez
Mar 5, 2016·Frontiers in Cell and Developmental Biology·Thomas KietzmannElitsa Y Dimova
Apr 5, 2016·Nature Medicine·Mohlopheni J MarakalalaEric J Rubin
Jun 2, 2016·Thorax·Moerida BeltonJon S Friedland
Jul 20, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan BravermanSarah A Stanley
Jan 27, 2017·Oncology Letters·Geng ZhangHai-Lun Wang

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Citations

Jun 20, 2020·Journal of Leukocyte Biology·Tamara Silva RodriguesVânia Luiza Deperon Bonato
Apr 2, 2019·Frontiers in Microbiology·Eun-Kyeong JoJae-Min Yuk
Oct 20, 2020·Frontiers in Cellular and Infection Microbiology·Bridgette M CummingAdrie J C Steyn
Oct 31, 2020·Cellular and Molecular Life Sciences : CMLS·Inaya HayekAnja Lührmann
Aug 10, 2019·Molecular Cancer Therapeutics·Mario I VegaAlan Lichtenstein
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Dilara Kiran, Randall J Basaraba
Aug 28, 2020·Cell Metabolism·Anne F McGettrick, Luke A J O'Neill
Apr 19, 2021·Clinical and Experimental Immunology·Manuel Othoniel López-TorresRogelio Hernández-Pando

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