Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response.

The FEBS Journal
Joo-Hyeon Lee, Dae-Sik Lim

Abstract

The Nbs1 protein associates with Mre11 and Rad50 proteins to form the Mre11-Rad50-Nbs1 complex, which plays an important role in the intracellular signaling pathway activated in response to DNA damage. Mutations in the genes for each of these three components of the Mre11-Rad50-Nbs1 complex result in human diseases characterized by genomic instability. Insight into the functions of Nbs1 in the DNA damage response mediated by the protein kinase, ataxia telangiectasia mutated, has been provided by recent studies. Nbs1 acts both as a downstream target of ataxia telangiectasia mutated in the S-phase checkpoint of the cell cycle as well as an upstream modulator or activator of ataxia telangiectasia mutated in the DNA damage response.

References

Feb 17, 1998·Biochemical and Biophysical Research Communications·K MatsuuraK Komatsu
Dec 2, 2000·Nature·B B Zhou, S J Elledge
Dec 13, 2000·Molecular and Cellular Biology·O K Mirzoeva, J H Petrini
Mar 10, 2001·Molecular and Cellular Biology·A Desai-MehtaP Concannon
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·M B Kastan, D S Lim
Jul 5, 2001·Molecular and Cellular Biology·G BuscemiD Delia
Oct 23, 2001·Advances in Cancer Research·Y Shiloh, M B Kastan
Jan 26, 2002·Molecular and Cellular Biology·Bo XuMichael B Kastan
Apr 6, 2002·Science·Arkady CelesteAndré Nussenzweig
Nov 7, 2002·Current Biology : CB·Junya KobayashiKenshi Komatsu
Jan 31, 2003·Nature·Christopher J Bakkenist, Michael B Kastan
Feb 28, 2003·Nature·Michal GoldbergStephen P Jackson
Feb 28, 2003·Nature·Grant S StewartStephen J Elledge
Oct 9, 2003·The EMBO Journal·Tamar UzielYosef Shiloh
Dec 6, 2003·The EMBO Journal·Christian T CarsonMatthew D Weitzman
Jun 4, 2004·Genes & Development·Risa KitagawaMichael B Kastan

❮ Previous
Next ❯

Citations

Dec 1, 2007·Breast Cancer Research and Treatment·Natalia BogdanovaThilo Dörk
Jul 7, 2009·Annual Review of Plant Biology·David ChevalierJohn C Walker
Mar 23, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Nataliya V SavinaRoza I Goncharova
Feb 17, 2007·Lancet Neurology·Brent L Fogel, Susan Perlman
Sep 11, 2016·Mechanisms of Ageing and Development·Stephan GasserFlorence S G Cheung
Oct 25, 2007·International Journal of Cancer. Journal International Du Cancer·Natalia BogdanovaThilo Dörk
Oct 27, 2015·Medical Oncology·Alina RosinhaRui Medeiros

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.