Dual role of substance P/GABA axons in cortical neurotransmission: synaptic triads on pyramidal cell spines and basket-like innervation of layer II-III calbindin interneurons in primate prefrontal cortex

Cerebral Cortex
R L JakabC Leranth

Abstract

In spite of accumulating evidence on the potent neuromodulatory, neuroprotective, trophic and memory-enhancing effects of the neuropeptide substance P (SP) in the cerebral cortex, the excitatory or inhibitory nature of the cortical SP innervation remains unclear and the postsynaptic targets of SP fibers are not defined. To obtain further insight into these issues, we have examined SP-containing axons and their postsynaptic targets in the prefrontal cortex of adult monkeys with single- and double label immunocytochemistry combined with light and correlated electron microscopy. SP fibers in the primate prefrontal cortex, unlike those in the rat cortex, preferentially innervate cortical layers I, II and upper layer III. Our results demonstrate for the first time that all SP-immunoreactive boutons in all cortical layers contain GABA. Of the entire sample of SP boutons, 53% synapse on dendritic shafts, 39% on dendritic spines and 8% on cell bodies. Another new finding is that synapse-forming SP boutons, in addition to their known innervation of pyramidal cells, form pericellular baskets around interneurons in layers II and upper III, a subpopulation of which contains calbindin D28k. Finally, the study also revealed that SP boutons f...Continue Reading

Citations

Oct 3, 1998·Brain Research. Molecular Brain Research·O ZachrissonS Brené
Nov 9, 2000·Clinical and Experimental Pharmacology & Physiology·P A TooneyL A Chahl
Feb 5, 2002·Annual Review of Physiology·Esther A NimchinskyKarel Svoboda
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R L Jakab, P S Goldman-Rakic
Oct 30, 2010·The Journal of Comparative Neurology·Lidia Blazquez-LlorcaJavier DeFelipe
Dec 2, 2004·Brain Research. Brain Research Reviews·Fernando Torrealba, Maria Angélica Carrasco
Jun 7, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stewart Shipp
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Feb 23, 2000·The Journal of Comparative Neurology·R L Jakab, P S Goldman-Rakic
Dec 30, 2014·Journal of Neurophysiology·Diana C RotaruGuillermo Gonzalez-Burgos
Jul 19, 2000·Journal of Neurochemistry·P D WalkerM J Bannon
Dec 28, 2017·PloS One·Benjamin HertlerAndreas Rüdiger Luft

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