PMID: 9183056Mar 1, 1997Paper

Dual role of testosterone in fenvalerate-treated mice with respect to thyroid function and lipid peroxidation

Journal of Applied Toxicology : JAT
P K Maiti, A Kar

Abstract

Effects of testosterone propionate (TP, 2.5 mg kg(-1) body weight) in fenvalerate-induced (120 mg kg(-1) body weight) thyroid dysfunction and lipid peroxidation were investigated in male mice. Testosterone propionate aggravated in the inhibition of hepatic type I iodothyronine 5'-monodeiodinase (5'D-I) activity, coupled with a decrease in serum triiodothyronine (T3) concentration in pesticide-treated mice. However, it could ameliorate the toxicity as indicated by decreased hepatic lipid peroxidation (LPO) with a marginal but significant increase in superoxide dismutase and catalase activities following fenvalerate treatment. While protective effects of testosterone on LPO indicated its antiperoxidative property, the decrease in 5'D-I activity could be because of the increased accumulation of fenvalerate in the tissues following TP administration.

Citations

Jan 31, 2012·Fish Physiology and Biochemistry·Wenshan ZhouXuezhen Zhang
Sep 4, 2009·Biological Trace Element Research·Belma GirayFiliz Hincal
Jun 13, 2002·Environmental Health Perspectives·Kembra L Howdeshell
Jun 5, 2010·Toxicology Mechanisms and Methods·Amar K ChandraMahitosh Sarkar
Mar 28, 2021·Environmental Research·Carmen FreireMariana F Fernández

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