PMID: 8612790Mar 25, 1996Paper

Dual role of tropomyosin on chemically modified actin filaments from skeletal muscle

FEBS Letters
Hajime HondaK Matsuno

Abstract

Actin filaments copolymerized with both intact and chemically modified actin monomers restored their sliding activity when they were supplemented with tropomyosin extracted from skeletal muscle. In contrast, the ATPase activation of the copolymers was decreased when supplemented with tropomyosin. The results indicate that tropomyosin along with actin monomers may facilitate sliding activity of the entire actin filament but suppress ATPase activation of intact actin monomers themselves. Accordingly, tropomyosin molecules could be viewed as playing a dual role of both mechanical and chemical regulation of actin monomers.

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Citations

Jan 19, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gerald BurgstallerOliver Eickelberg
Feb 3, 2006·Journal of Biochemistry·Hiroaki Mizuno, Hajime Honda
Jul 21, 2011·Journal of Tissue Engineering·Fahsai KantawongMatthew J Dalby
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·P VanBurenD M Warshaw
Oct 17, 2002·Journal of Molecular Biology·Juliette Van DijkPatrick Chaussepied
Nov 24, 2004·Bio Systems·Kuniyuki HatoriHajime Honda

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