Dual roles for immunity in gastrointestinal cancers.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cristina Ferrone, Glenn Dranoff

Abstract

Histopathologic examination reveals that most human tumors are associated with diverse immune cell infiltrates, but the roles of host reactions in disease pathogenesis and prognosis remain to be fully clarified. Recent investigations in genetically engineered murine tumor models have uncovered dual functions for immune responses during cancer development and progression. Alterations in tumor cell gene expression profiles and coding sequences may trigger the activation of cytotoxic lymphocytes, which act to restrain tumor growth. In contrast, persistent inflammatory reactions, which may be driven by infection, environmental toxins, or impaired immune regulation, create a microenvironment that fosters tumor cell growth, survival, invasion, and dissemination. The dynamic interplay of these competing responses appears to be a critical event in cancer pathogenesis, with tumor promotion and immune evasion proving dominant in clinically evident disease. Nonetheless, longitudinal studies of patient cohorts have demonstrated that particular histopathologic and genetic signatures of cytotoxic lymphocyte reactions provide important prognostic information. Here, we discuss the dual roles of immunity in cancer development, focusing on gastr...Continue Reading

References

Oct 24, 1986·Science·K J TraceyJ D Albert
Jan 1, 1985·Immunogenetics·R D SalterP Cresswell
Aug 12, 1994·Science·E Kopp, S Ghosh
May 20, 1993·The New England Journal of Medicine·A B LowenfelsL Domellöf
Nov 14, 1997·The New England Journal of Medicine·M FrischM Melbye
Mar 28, 1998·The Journal of Experimental Medicine·S D SpencerM Aguet
Jul 22, 1998·The Journal of Experimental Medicine·Y NakamotoF V Chisari
Jan 23, 1999·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·A Ekbom
Mar 18, 1999·The New England Journal of Medicine·J LagergrenO Nyrén
Jan 29, 2000·Alimentary Pharmacology & Therapeutics·J EadenJ Mayberry
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K A EatonT Thevenot
Sep 15, 2001·The New England Journal of Medicine·J G Fox, T C Wang
Feb 16, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gennaro GaliziaFerdinando De Vita
Feb 28, 2002·Journal of Hepatology·Annika BergquistUlrika Broomé
May 2, 2002·Cell·Sankar Ghosh, Michael Karin
Nov 21, 2002·Journal of the National Cancer Institute·Céu FigueiredoManuel Sobrinho-Simões
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yue WangMasao Omata
Mar 4, 2003·Gastroenterology·Gregory P BoivinRobert J Coffey
Jul 29, 2003·Journal of Surgical Oncology·Yuan-Chang Chung, Ya-Fen Chang
Oct 3, 2003·Nature Reviews. Immunology·David H Raulet
Aug 27, 2004·Nature·Eli PikarskyYinon Ben-Neriah
Oct 28, 2004·Gastroenterology·F Xavier BoschRamon Cléries
Dec 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sarah L PullThaddeus S Stappenbeck
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Apr 14, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Masayuki FukataMaria T Abreu
May 19, 2005·Cancer Research·Susan E ErdmanDavid B Schauer
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
May 12, 2006·Nature·John L LangowskiMartin Oft
Sep 1, 2006·The New England Journal of Medicine·Monica M BertagnolliUNKNOWN APC Study Investigators

❮ Previous
Next ❯

Citations

Feb 26, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Simon M DenleyColin J McKay
Aug 10, 2011·Nature Reviews. Clinical Oncology·Shuji OginoGlenn Dranoff
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mei NieKarl Matter
Jul 4, 2012·Journal of Biomedicine & Biotechnology·Ioannis L AivaliotisVassilis Zoumpourlis
Feb 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Teppei MorikawaShuji Ogino
Dec 16, 2011·Journal of Translational Medicine·Bernard A FoxMary L Disis
Jan 17, 2013·World Journal of Gastroenterology : WJG·Yi-Fang Han, Guang-Wen Cao
May 16, 2013·World Journal of Gastroenterology : WJG·Lian-Zhen YuRui-Hua Shi
Jan 25, 2013·World Journal of Gastroenterology : WJG·Fabio GrizziLuigi Laghi
Jan 3, 2014·Clinical & Developmental Immunology·Dang WuJian Huang
Jan 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-Feng MiaoHui-Mian Xu
Oct 23, 2012·Digestive Diseases and Sciences·Juliana Garcia de OliveiraAna Elizabete Silva
Oct 15, 2014·Immunotherapy·Sandip P PatelMichael A Morse
Dec 25, 2010·Logopedics, Phoniatrics, Vocology·Amanda I Gillespie, Katherine Verdolini Abbott
Jun 5, 2013·Expert Review of Clinical Immunology·Ryan TrowbridgeDevendra K Agrawal
Jan 23, 2016·Biomaterials·C G Da SilvaLuis J Cruz
Feb 15, 2013·Expert Opinion on Drug Delivery·Paolo GiunchediGiovanna Rassu
May 28, 2013·The Journal of Surgical Research·Sumiya IshigamiShoji Natsugoe
Jul 14, 2012·Human Immunology·Xiaohai Zhang, Elaine F Reed
Jan 30, 2014·Protein & Cell·Ryan KolbWeizhou Zhang
Feb 6, 2014·Oncoimmunology·Kristen B Long, Gregory L Beatty
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 29, 2016·Cancer Letters·Yong XinGuan Jiang
Sep 10, 2016·PloS One·Fangyi GuNeil E Caporaso
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J GoodwinStephen D Hursting
Mar 11, 2017·Journal of Oncology Practice·Mingen LiuGregory L Beatty
Jul 5, 2017·Biochemical Society Transactions·Pernille Hojman
Aug 22, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Yuan ChenWendong Gu
Sep 26, 2014·World Journal of Gastroenterology : WJG·Vincenzo FormicaMario Roselli
Jan 14, 2020·Expert Review of Clinical Immunology·Mahdi GouravaniNima Rezaei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved