Dual roles of autologous CD8+ T cells in hematopoietic progenitor cell mobilization and engraftment

Transfusion
Athena RussellAbba C Zubair

Abstract

Poor marrow cellularity alone cannot explain poor hematopoietic progenitor cell (HPC) mobilization. This study assessed the role of CD8+ T cells in HPC cell mobilization and engraftment. Mobilization and engraftment were assessed in 192 autologous HPC donors. CD34+, CD4+, and CD8+ T-cell contents in apheresis products were evaluated. Using a chemotaxis assay, we assessed the effect of purified autologous CD8+ T cells from low and high mobilizers on HPC migration from high to low stromal cell-derived factor (SDF-1α) concentration gradients. We also assessed CD8+ T-cell content association with days to neutrophil engraftment. The median number of CD34+ cells/kg was 4.7 × 10(6) . Patients were categorized according to their total CD34+ cell collection quartile distribution into low, moderate, and high mobilizers. We found that HPC products from low mobilizers contained more CD8+ T cells than HPC products from moderate and high mobilizers. Chemotaxis assays showed depletion of CD8+ T cells enhances HPC mobilization independent of SDF-1α concentration. Neutrophil engraftment analysis showed that the higher the CD8+ T-cell content per unit CD34+ cell, the faster the rate of engraftment. Our findings suggest CD8+ T cells inhibit HPC m...Continue Reading

References

Oct 1, 1992·The Clinical Investigator·U R HenggeM Goos
May 9, 2000·Cancer Treatment and Research·M Körbling
Sep 23, 2000·Baillière's Best Practice & Research. Clinical Haematology·M Körbling

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Citations

Jul 10, 2021·Stem Cell Reports·Lorena Lobo de Figueiredo-PontesMeritxell Alberich-Jorda
Dec 25, 2021·Expert Review of Hematology·Guro Kristin MelveHåkon Reikvam

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