Dual roles of nitric oxide in the regulation of tumor cell response and resistance to photodynamic therapy

Redox Biology
Valentina RapozziBenjamin Bonavida

Abstract

Photodynamic therapy (PDT) against cancer has gained attention due to the successful outcome in some cancers, particularly those on the skin. However, there have been limitations to PDT applications in deep cancers and, occasionally, PDT treatment resulted in tumor recurrence. A better understanding of the underlying molecular mechanisms of PDT-induced cytotoxicity and cytoprotection should facilitate the development of better approaches to inhibit the cytoprotective effects and also augment PDT-mediated cytotoxicity. PDT treatment results in the induction of iNOS/NO in both the tumor and the microenvironment. The role of NO in cytotoxicity and cytoprotection was examined. The findings revealed that NO mediates its effects by interfering with a dysregulated pro-survival/anti-apoptotic NF-κB/Snail/YY1/RKIP loop which is often expressed in cancer cells. The cytoprotective effect of PDT-induced NO was the result of low levels of NO that activates the pro-survival/anti-apoptotic NF-κB, Snail, and YY1 and inhibits the anti-survival/pro-apoptotic and metastasis suppressor RKIP. In contrast, PDT-induced high levels of NO result in the inhibition of NF-kB, Snail, and YY1 and the induction of RKIP, all of which result in significant ant...Continue Reading

References

Jul 15, 1992·Journal of Photochemistry and Photobiology. B, Biology·D Kessel
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I B RoninsonI Pastan
Feb 1, 1995·The British Journal of Surgery·A M AbulafiN S Williams
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Feb 25, 2000·Photochemistry and Photobiology·D KesselJ J Reiners
Dec 2, 2000·Journal of Photochemistry and Photobiology. B, Biology·A C Moor
Nov 14, 2001·Journal of Photochemistry and Photobiology. B, Biology·J G HanlonG Singh
Mar 13, 2002·Gut·S G BownA W R Hatfield
Aug 16, 2002·Lasers in Medical Science·L Brancaleon, H Moseley
Jan 31, 2003·Gastrointestinal Endoscopy·Tetsuya NakamuraMichimaro Ejiri
Mar 28, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Nancy L OleinickIrina Belichenko
Mar 28, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·David Kessel
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Jun 10, 2003·International Journal of Gastrointestinal Cancer·Hideo YanaiTeruaki Sekine
Feb 26, 2004·Photochemistry and Photobiology·Mihoko NonakaTsugio Inokuchi
Oct 27, 2004·Lasers in Medical Science·Asta JuzenieneJohan Moan
Feb 3, 2005·Cancer Biology & Therapy·Robert W RobeySusan E Bates
Mar 2, 2005·Cancer Biology & Therapy·Theresa M Busch, Stephen M Hahn
May 12, 2005·Experimental Dermatology·F CórdobaV von Felbert
Jun 1, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Stanley S StylliPriya Rajendra
Jan 5, 2006·Genes & Development·Wei-Xing Zong, Craig B Thompson
Mar 29, 2006·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Asta JuzenieneJohan Moan
Apr 15, 2006·Lasers in Surgery and Medicine·Barbara W HendersonJohn W Snyder
Jun 22, 2006·Lasers in Surgery and Medicine·Paul J Muller, Brian C Wilson
Jun 22, 2006·Lasers in Surgery and Medicine·K L DuS M Hahn
Aug 17, 2006·Antioxidants & Redox Signaling·Lisa A RidnourJeffrey S Isenberg
Aug 19, 2007·Biochimica Et Biophysica Acta·Esther BuytaertPatrizia Agostinis
Feb 6, 2008·Lasers in Medical Science·K PlaetzerT Kiesslich
Apr 11, 2008·Physics in Medicine and Biology·Brian C Wilson, Michael S Patterson
Apr 29, 2008·Free Radical Biology & Medicine·Douglas D ThomasDavid A Wink
May 14, 2008·Current Molecular Medicine·Nele VanlangenakkerPeter Vandenabeele
Jun 27, 2008·Cellular and Molecular Life Sciences : CMLS·H Lage
Nov 4, 2008·Expert Opinion on Drug Delivery·Stéphane A SibaniRyan F Donnelly
Apr 22, 2009·Journal of Photochemistry and Photobiology. B, Biology·Kimberley J ReevesNicola J Brown
May 21, 2009·Journal of Hepato-biliary-pancreatic Sciences·Fei GaoZhao-Shen Li
Sep 4, 2009·Trends in Molecular Medicine·Matthew W FosterJonathan S Stamler

❮ Previous
Next ❯

Citations

Oct 9, 2015·Redox Biology·Jordi Muntané, Benjamin Bonavida
Jun 26, 2015·Bioconjugate Chemistry·Valentina RapozziGreta Varchi
May 14, 2016·International Immunopharmacology·Rajapaksha Gedara Prasad Tharanga JayasooriyaGi-Young Kim
Sep 9, 2016·Photochemistry and Photobiology·Jonathan M FaheyAlbert W Girotti
May 8, 2018·Journal of Drug Targeting·Lingyun YiGuangxi Zhai
Sep 24, 2019·Photochemistry and Photobiology·Albert W Girotti
Aug 29, 2020·Biomaterials Science·Susan OliverCyrille Boyer
Sep 20, 2019·Antioxidants·Emily Hays, Benjamin Bonavida
Feb 8, 2020·Breast Cancer : Basic and Clinical Research·Deepshikha MishraDebabrata Banerjee
Sep 2, 2019·Journal of Photochemistry and Photobiology. B, Biology·Stanislav V RodkinAnatoly B Uzdensky
Sep 11, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Helmut SchweiklWolfgang Buchalla
Aug 31, 2021·Neurochemistry International·Marek Mazurek, Radosław Rola

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.