Dual route vaccination for plague with emergency use applications

Vaccine
B D MooreE D Williamson

Abstract

Here, we report a dual-route vaccination approach for plague, able to induce a rapid response involving systemic and mucosal immunity, whilst also providing ease of use in those resource-poor settings most vulnerable to disease outbreaks. This novel vaccine (VypVaxDuo) comprises the recombinant F1 and V proteins in free association. VypVaxDuo has been designed for administration via a sub-cutaneous priming dose followed by a single oral booster dose and has been demonstrated to induce early onset immunity 14 days after the primary immunisation; full protective efficacy against live organism challenge was achieved in Balb/c mice exposed to 2 × 104 median lethal doses of Yersinia pestis Co92, by the sub-cutaneous route at 25 days after the oral booster immunisation. This dual-route vaccination effectively induced serum IgG and serum and faecal IgA, specific for F1 and V, which constitute two key virulence factors in Y. pestis, and is therefore suitable for further development to prevent bubonic plague and for evaluation in models of pneumonic plague. This is an essential requirement for control of disease outbreaks in areas of the world endemic for plague and is supported further by the observed exceptional stability of the prima...Continue Reading

Citations

Apr 12, 2019·Clinical and Experimental Immunology·E D Williamson, G E Westlake
Jul 19, 2019·Clinical and Experimental Immunology·R R C New
Feb 23, 2019·NPJ Vaccines·Wei Sun, Amit K Singh
Feb 5, 2021·International Journal of Pharmaceutics·Rahul G Ingle, Wei-Jie Fang
Jun 19, 2021·Applied Microbiology and Biotechnology·Jason A RosenzweigAshok K Chopra

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