Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer

Cancer Science
Daisuke ItoKiyotsugu Yoshida

Abstract

Colorectal cancer is a common cancer and a leading cause of cancer-related death worldwide. The liver is a dominant metastatic site for patients with colorectal cancer. Molecular mechanisms that allow colorectal cancer cells to form liver metastases are largely unknown. Activation of epithelial-mesenchymal transition is the key step for metastasis of cancer cells. We recently reported that dual-specificity tyrosine-regulated kinase 2 (DYRK2) controls epithelial-mesenchymal transition in breast cancer and ovarian serous adenocarcinoma. The aim of this study is to clarify whether DYRK2 regulates liver metastases of colorectal cancer. We show that the ability of cell invasion and migration was abrogated in DYRK2-overexpressing cells. In an in vivo xenograft model, liver metastatic lesions were markedly diminished by ectopic expression of DYRK2. Furthermore, we found that patients whose liver metastases expressed low DYRK2 levels had significantly worse overall and disease-free survival. Given the findings that DYRK2 regulates cancer cell metastasis, we concluded that the expression status of DYRK2 could be a predictive marker for liver metastases of colorectal cancer.

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Citations

Oct 5, 2018·International Journal of Molecular Sciences·Gianluca LopezAlessandro Del Gobbo
Sep 8, 2018·Cancer Science·Satomi Yogosawa, Kiyotsugu Yoshida
Apr 3, 2020·International Journal of Oncology·Tomotaka KumamotoKiyotsugu Yoshida
May 29, 2020·Cellular and Molecular Life Sciences : CMLS·Alejandro Correa-SáezMarco A Calzado
Mar 5, 2019·Current Medicinal Chemistry·Narges DastmalchiMirsaed Miri Nargesi
Dec 31, 2020·The Journal of Biological Chemistry·Vasudha TandonSourav Banerjee
Feb 16, 2021·Cancer Treatment and Research Communications·Satomi YogosawaKiyotsugu Yoshida
Dec 4, 2020·Cell Death and Differentiation·Rita MorenoLaureano de la Vega
May 15, 2021·OncoTargets and Therapy·Wubin ZhengWeiwei Tang

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Methods Mentioned

BETA
Assay
xenograft

Software Mentioned

GraphPad
StatMate

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