PMID: 9544662Apr 17, 1998Paper

Dual spillover problem in the myocardial septum with nitrogen-13-ammonia flow quantitation

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Jens D HoveM E Phelps

Abstract

Conventional cardiac PET modeling techniques for [13N]ammonia flow determination do not fully account for the effects of spillover of activity from the right ventricle (RV) onto the activity in the myocardial septum. The purpose of this study was to investigate and to quantitatively account and correct for this effect. Simulations were performed to determine the error introduced by conventional quantitation using septal time-activity curves, which only account for left ventricle (LV) spillover. Furthermore, we explored two separate methods to account for the dual spillover problem: direct estimation of the RV and LV spillover fractions incorporated into the [13N]ammonia model by using the LV and RV input functions in the fit and estimation of the relative dispersion and time shift between the LV and RV input functions by fitting using only the LV input function. The simulated curves were fitted using a two-compartment [13N]ammonia model. Flow estimates from the conventional model and the models including either of the two correction procedures were compared with canine microsphere data. The influence of RV spillover on flow estimation in the septum is determined by several parameters (e.g., dispersion between the RV and LV inpu...Continue Reading

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