Dual stimulation using corifollitropin alfa in 54 Bologna criteria poor ovarian responders - a case series

Reproductive Biomedicine Online
Birgit AlsbjergPeter Humaidan

Abstract

What are the reproductive outcomes of Bologna criteria poor responders undergoing dual stimulation (DuoStim) and subsequent cryopreserved embryo transfer? Case series of patients treated during the period August 2015 to March 2018 in a public fertility clinic. The study included 54 Bologna criteria poor responder IVF patients younger than 42 years receiving a follicular stimulation (DuoStim 1) followed by a luteal phase stimulation (DuoStim 2) within the same cycle, both stimulations being performed with corifollitropin alfa followed by a subsequent cryopreserved embryo transfer cycle. The primary endpoint was the number of oocytes retrieved in DuoStim 1 compared with DuoStim 2. The secondary endpoint was ongoing pregnancy rate (OPR) at 12 weeks of gestation. The mean number of oocytes retrieved in DuoStim 1 and DuoStim 2 was 2.4 ± 2.1 versus 3.7 ± 2.6, respectively; thus, a total of 1.2 (95% CI, 0.46-1.96) more oocytes was retrieved in DuoStim 2 compared with DuoStim 1 (P = 0.002). The OPR at 12 weeks was 20% (11/54) in this poor ovarian response population with a mean age of 36.7 years. Luteal phase stimulation results in more oocytes in poor responders compared with follicular phase stimulation. DuoStim, using corifollitropi...Continue Reading

Associated Clinical Trials

Citations

Sep 22, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gustavo N CecchinoJuan A García-Velasco
Mar 25, 2020·International Journal of Molecular Sciences·Antoine Abu-MusaPeter Humaidan
Aug 28, 2020·Therapeutic Advances in Reproductive Health·Panagiotis DrakopoulosChristophe Blockeel
Mar 11, 2020·Frontiers in Endocrinology·Ernesto BoschPeter Humaidan
Jul 30, 2019·Frontiers in Endocrinology·Peter HumaidanThor Haahr
Oct 2, 2019·Frontiers in Endocrinology·Thor HaahrPeter Humaidan
May 26, 2021·Reproductive Sciences·Michail KalinderisRoy Homburg
Jun 24, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Selmo GeberMarcos Sampaio
Jul 16, 2021·Therapeutic Advances in Reproductive Health·Mehtap PolatHakan Yarali

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