Dual stimuli-responsive Fe3 O4 graft poly(acrylic acid)-block-poly(2-methacryloyloxyethyl ferrocenecarboxylate) copolymer micromicelles: surface RAFT synthesis, self-assembly and drug release applications

Journal of Nanobiotechnology
Yuan WangYu-Yu Su

Abstract

Stimuli-responsive polymer materials are a new kind of intelligent materials based on the concept of bionics, which exhibits more significant changes in physicochemical properties upon triggered by tiny environment stimuli, hence providing a good carrier platform for antitumor drug delivery. Dual stimuli-responsive Fe3O4 graft poly(acrylic acid)-block-poly(2-methacryloyloxyethyl ferrocenecarboxylate) block copolymers (Fe3O4-g-PAA-b-PMAEFC) were engineered and synthesized through a two-step sequential reversible addition-fragmentation chain transfer polymerization route. The characterization was performed by FTIR, 1H NMR, SEC, XRD and TGA techniques. The self-assembly behavior in aqueous solution upon triggered by pH, magnetic and redox stimuli was investigated via zeta potentials, vibration sample magnetometer, cyclic voltammetry, fluorescent spectrometry, dynamic light scattering, XPS, TEM and SEM measurements. The experimental results indicated that the Fe3O4-g-PAA-b-PMAEFC copolymer materials could spontaneously assemble into hybrid magnetic copolymer micromicelles with core-shell structure, and exhibited superparamagnetism, redox and pH stimuli-responsive features. The hybrid copolymer micromicelles were stable and nontoxic...Continue Reading

References

Nov 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Geneviève GaucherJean-Christophe Leroux
Aug 6, 2008·Small·Shirly Ben-David MakhlufAharon Gedanken
Mar 18, 2009·Journal of the American Chemical Society·Akamol KlaikherdS Thayumanavan
Jun 7, 2013·Advanced Materials·Jinqiang WangZhongwei Gu
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Mar 29, 2014·Drug Delivery·Shambhu Dokania, Amita K Joshi
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Yongling DingJun Yan
Mar 23, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying-wen HuFu-qiang Hu
Jul 30, 2015·Chemistry : a European Journal·Sudhina GuragainYusuke Yamauchi
Oct 21, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Govinda GhimireTakashi Ito
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Xuan LiuSeeram Ramakrishna
Apr 22, 2016·Angewandte Chemie·Juan M PriegueJavier Montenegro
May 7, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Zi-Quan Cao, Guo-Jie Wang
Aug 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiao-Mei ZhangBang-Jing Li

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
XRD
X
-ray
dynamic light scattering

Software Mentioned

mathord

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.