Dual-Stimuli-Responsive Multifunctional Gd2Hf2O7 Nanoparticles for MRI-Guided Combined Chemo-/Photothermal-/Radiotherapy of Resistant Tumors.

ACS Applied Materials & Interfaces
Ye KuangRenjun Pei

Abstract

The design and synthesis of a novel generation of a nanoscaled platform with imaging-guided therapy remain a real challenge. It can not only improve the imaging sensitivity of tumor tissues for guiding all kinds of treatments but also reduce the harm for healthy tissues. Here, polydopamine (PDA), polyethylene glycol (PEG), and c(RGDyK) peptide (RGD)-modified and cisplatin-loaded Gd2Hf2O7 nanoparticles (Gd2Hf2O7@PDA@PEG-Pt-RGD NPs) are designed for magnetic resonance imaging (MRI)-guided combined chemo-/photothermal-/radiotherapy of resistant tumors. The as-prepared NPs display high relaxivity (r1 = 38.28 mM-1 s-1) as an MRI contrast agent because of their ultrasmall size and surface modification with polyacrylic acid and PDA. Gd2Hf2O7@PDA@PEG-Pt-RGD NPs exhibit pH and NIR dual-stimuli responsiveness for cisplatin release. Based on competent NIR absorption and high X-ray attenuation efficiency, Gd2Hf2O7@PDA@PEG-Pt-RGD NPs show potential photothermal effect by exposing to an 808 nm NIR laser and significantly improve the generation of reactive oxygen species after X-ray radiation. Combined chemo-/photothermal-/radiotherapy can effectively treat the resistant A549R cells, providing the enhanced therapeutic efficiency to cancer tis...Continue Reading

References

Mar 19, 2016·Cancer Letters·Chloé RancouleCyrus Chargari
Dec 22, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sylvie BonvalotJean-Charles Soria
Feb 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·He WeiMoungi G Bawendi
Aug 26, 2017·Scientific Reports·Neeraj KumarJane Catherine Ngila
Jan 23, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Min QiuZhiyuan Zhong
Jun 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E ChajonE Deutsch
May 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yi CaoRenjun Pei

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Citations

Oct 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fengqin XuZhenxin Wang
Mar 5, 2021·International Journal of Nanomedicine·Ruixin JiaYe Bi

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