Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer.

Current Medicinal Chemistry
Sitao ZhangTingting Liu

Abstract

Currently, cancer continues being a dramatically increasing and serious threat to public health. Although many anti-tumor agents have been developed in recent years, the survival rate of patients is not satisfactory. The poor prognosis of cancer patients is closely related to the occurrence of drug resistance. Therefore, it is urgent to develop new strategies for cancer treatment. Multi-target therapies aim to have additive or synergistic effects and reduce the potential for the development of resistance by integrating different pharmacophores into a single drug molecule. Given the fact that majority of diseases are multifactorial in nature, multi-target therapies are being exploited with increasing intensity, which has brought improved outcomes in disease models and obtained several compounds that have entered clinical trials. Thus, it is potential to utilize this strategy for the treatment of BRD4 related cancers. This review focuses on the recent research advances of dual-target inhibitors based on BRD4 in the aspect of anti-tumor. We have searched the recent literatures about BRD4 inhibitors from the online resources and databases, such as pubmed, elsevier and google scholar. In the recent years, many efforts have been take...Continue Reading

Citations

Feb 16, 2021·Frontiers in Oncology·Tongyue ZhangLimin Xia
Mar 26, 2021·European Journal of Medicinal Chemistry·Zheng ZhangTingting Liu
Nov 24, 2021·Journal of Medicinal Chemistry·Shu-Ping WangYun-Gen Xu

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