Dual-targeted photothermal agents for enhanced cancer therapy.

Chemical Science
Kaiye WangBo Tang

Abstract

Photothermal therapy, in which light is converted into heat and triggers local hyperthermia to ablate tumors, presents an inherently specific and noninvasive treatment for tumor tissues. In this area, the development of efficient photothermal agents (PTAs) has always been a central topic. Although many efforts have been made on the investigation of novel molecular architectures and photothermal materials over the past decades, PTAs can cause severe damage to normal tissues because of the poor tumor aggregate ability and high irradiation density. Recently, dual-targeted photothermal agents (DTPTAs) provide an attractive strategy to overcome these problems and enhance cancer therapy. DTPTAs are functionalized with two classes of targeting units, including tumor environment targeting sites, tumor targeting sites and organelle targeting sites. In this perspective, typical targeted ligands and representative examples of photothermal therapeutic agents with dual-targeted properties are systematically summarized and recent advances using DTPTAs in tumor therapy are highlighted.

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Citations

Jun 18, 2021·Chemical Communications : Chem Comm·Kaiye WangBo Tang
Aug 7, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chong MaZhigang Xie
Aug 11, 2021·Pharmaceutics·Elham RastegariYueh Chien
Sep 11, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qun GuanYu-Bin Dong

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Methods Mentioned

BETA
surface plasmon resonance
xenograft
fluorescence imaging
oncotherapy

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