Dual-time-point FDG-PET/CT for the detection of hepatic metastases.

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Albert DirisamerWerner Langsteger

Abstract

To prove the sensitivity of dual-time-point imaging with 18F-flourodeoxyglucose-positron emission tomography (18F-FDG-PET) of the liver to evaluate possible changes in the tumor-to-background ratio considering an improved detection rate of liver lesions. Image acquisition for the first whole-body scan started at a mean time point of 69 min (55-110 min). The mean time interval between the injection of 18F-FDG and the second delayed scan was 100 min (85-166 min). Of 90 proven liver metastases in 34 patients, the first scan detected 53 (59%) liver lesions correctly, whereas in the second, delayed scan 81 (90%) lesions were diagnosed correctly (p<0.001). The mean Standardized uptake values in the first and second delayed scan were 6.59 g/ml versus 8.09 g/ml, respectively (p<0.001). Tumor-to-background ratio of the first and second delayed scan were 2.0 and 2.7, respectively (p=0.04). Dual-time-point-imaging of the liver showed a significant increase of tumor-to-background ratio and hypermetabolic lesion diameter. Although, 30% of all verified liver lesions could only be detected in the second delayed scan 10% of all malignant liver lesions were missed with FDG-PET.

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Citations

Jul 20, 2011·Der Radiologe·J KlasenD Blondin
Jan 31, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Gang ChengAbass Alavi
Aug 5, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jeong Won LeeTae-Sung Kim
Dec 19, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Caecilia S ReinerPatrick Veit-Haibach
Oct 24, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gang ChengScott R Akers
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Jan 1, 2011·PET Clinics·Imene ZerizerAdil Al-Nahhas
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Apr 16, 2011·Nuclear Medicine and Biology·Kazuo KubotaHitoshi Shibuya
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Oct 21, 2016·Clinical Nuclear Medicine·Zhanli FuQian Li
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Sep 22, 2020·Nuclear Medicine Communications·Bekir TasdemirCanan Can
Dec 12, 2020·Nuclear Medicine Communications·Francisco Fuentes-OcampoIgnasi Carrió
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