Abstract
Heart failure is associated with activation of the sympathetic nervous system and downregulation of beta-receptors. However, the coupling between cardiac sympathetic neuronal function and the beta-receptor during the development of hypertensive heart failure is not clear. We determined cardiac neuronal function and beta-receptors with a dual-tracer method of [131I]metaiodobenzylguanidine (MIBG) and 125I-cyanopindolol (ICYP) in Dahl salt-sensitive (DS) and salt-resistant (DR) rats. The rats were fed an 8% NaCl diet after the age of 6 weeks. Blood pressure was raised to >200 mm Hg at 12 weeks in DS rats and remained elevated until 18 weeks, but only slightly in DR rats. Left ventricular (LV) function of DS rats was preserved at 12 weeks but deteriorated at 18 weeks. Despite a 56% reduction of cardiac norepinephrine (NE) content at 12 weeks in DS rats, neither MIBG nor ICYP uptake in DS rats was different from that of DR rats. At 18 weeks, both MIBG and ICYP uptakes decreased, by 52% and 39%, respectively, in association with 71% reduction of cardiac NE, in DS rats. MIBG uptake of the LV was homogeneous at 6 weeks but was lower in the LV endocardial regions at 18 weeks in DS rats. The present results indicate that cardiac sympathe...Continue Reading
References
Jan 1, 1979·Clinical and Experimental Hypertension : CHE·R FriedmanJ Iwai
Mar 15, 1978·Experientia·M Göthert, J M Rieckesmann
Mar 1, 1992·The Journal of Clinical Investigation·M R BristowS V Karwande
Apr 1, 1991·The American Journal of Physiology·W M Moran, J D Valentich
Jan 1, 1989·Journal of Hypertension·T HanoJ Rho
Oct 1, 1989·The Journal of Clinical Investigation·C S LiangS Sakamoto
Dec 1, 1989·The Journal of Clinical Investigation·D E VatnerC J Homcy
Jan 1, 1968·Circulation Research·L K DahlG J Leitl
Jul 1, 1984·Hypertension·M A PfefferJ Iwai
Jul 1, 1983·Hypertension·R D BuñagS Sasaki
Apr 15, 1982·Biochemical Pharmacology·J Marín, L Recio
Jan 1, 1995·Journal of the American College of Cardiology·M BöhmE Erdmann
Mar 1, 1994·Journal of the American College of Cardiology·S L Beau, J E Saffitz
Jan 1, 1996·Cardiovascular Research·G A SomsenP A van Zwieten
Sep 1, 1965·The American Journal of Medicine·C A CHIDSEYA G MORROW
Citations
Mar 31, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Albert Flotats, Ignasi Carrió
Oct 9, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Albert Flotats, Ignasi Carrió
Nov 7, 2002·Biochemical and Biophysical Research Communications·Tohru YamakuniYasushi Ohizumi
Nov 15, 2001·Pharmacology & Therapeutics·G Eisenhofer
Aug 9, 2003·Journal of the American College of Cardiology·Akihiko IgawaHiroshi Inoue
Jan 15, 2002·Cell Research·H LiJ Fei
Aug 27, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Naohiro YoshidaHiroshi Inoue
Apr 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Makoto NonomuraHiroshi Inoue
Jun 27, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruo NakadateHiroshi Inoue
Jan 28, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Akira MatsukiHiroshi Inoue
Feb 1, 2003·Japanese Heart Journal·Akihiko IgawaHiroshi Inoue
Apr 16, 2013·Antioxidants & Redox Signaling·Nina KaludercicNazareno Paolocci
Jul 11, 2001·Journal of Molecular and Cellular Cardiology·N R DiPaolaC Schomisch Moravec
Mar 13, 2012·Heart Failure Clinics·Patrick Collier, Kenneth M McDonald
Jan 15, 2014·Journal of Molecular and Cellular Cardiology·Nina KaludercicFabio Di Lisa
Mar 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Nozomu FujiiHiroshi Inoue
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A IgawaH Inoue
Mar 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Mitsuo SobajimaHiroshi Inoue