Dual tracer single breath studies of gas transport in the lung

Respiration Physiology
L A EngelY Fukuchi

Abstract

We studied the ratio of the expired He and SF6 concentrations (He/SF6) after 1 litre inspirations of a gas mixture containing 5% of He and SF6. Five subjects aged 49 to 60 yrs. performed the maneuvers with both inspiration and expiration at 0.2--0.41/s or 1.5--2.01/s. In all subjects separation of the tracer gases was observed, the He/SF6 falling early to a minimum of 0.80 +/- 0.01 (mean +/- 1 SE), and increasing gradually during expiration to a maximum of 1.08 +/- 0.01. The slope of the SF6 alveolar plateau was 1.45 +/- 0.09 times that for He. Computer simulations of simultaneous convection and diffusion in an axisymmetrical series lung model predicted a pattern of He/SF6 early in expiration which corresponded qualitatively to that observed experimentally. However, the model did not predict a rising He/SF6 ratio late in expiration. This was simulated only by incorporation of parallel inhomogeneity with sequential emptying into the model analysis. Consideration of Taylor type dispersion and airway asymmetry did not influence the simulations significantly. The results suggest that differing slopes of the alveolar plateau of two tracer gases may be due to diffusion dependent concentration differences among lung units ventilated i...Continue Reading

References

Nov 1, 1975·Respiration Physiology·L M LacquetM Paiva
Jun 1, 1974·Bulletin of Mathematical Biology·M R Davidson, J M Fitz-Gerald
Dec 1, 1972·Computers and Biomedical Research, an International Journal·M Paiva
Sep 1, 1972·The Bulletin of Mathematical Biophysics·P W SchererN M Greene
Aug 1, 1971·Respiration Physiology·G CummingS B Preston
Jan 1, 1966·Respiration Physiology·G CummingI Parker

Citations

Apr 1, 1980·Pflügers Archiv : European journal of physiology·S C LuijendijkW M Salet
Mar 1, 1989·Pflügers Archiv : European journal of physiology·A C SchrikkerS C Luijendijk
Jan 18, 2006·Medical & Biological Engineering & Computing·J K K KanhaiG J Puppels
Jun 1, 1980·Computers and Biomedical Research, an International Journal·M Paiva
Sep 1, 1980·Respiration Physiology·Y FukuchiL A Engel
Sep 1, 1981·Respiration Physiology·L A Engel, M Paiva
Jun 1, 1981·Respiration Physiology·M Paiva, L A Engel
Mar 1, 1982·Respiration Physiology·S KellyL A Engel
Jun 1, 1984·Respiration Physiology·M PaivaJ C Yernault
Apr 1, 1991·Respiration Physiology·G R NeufeldP W Scherer
May 14, 2005·Respiratory Physiology & Neurobiology·Chantal Darquenne, G Kim Prisk
Dec 1, 1986·British Journal of Industrial Medicine·J J Opdam, J F Smolders
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·M L RubioN Gonzalez Mangado
Nov 19, 2003·IEEE Transactions on Bio-medical Engineering·J K K KanhaiG J Puppels
Aug 16, 2005·Respiratory Physiology & Neurobiology·Jesús Ruiz-CabelloManuel Cortijo
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·José M Pérez-SánchezJesús Ruiz-Cabello
Nov 2, 2014·The European Respiratory Journal·Philipp Latzin, Bruce Thompson
Apr 20, 2004·Journal of Applied Physiology·I Mark Olfert, G Kim Prisk
Oct 23, 2002·Journal of Applied Physiology·Brigitte DutrieueG Kim Prisk

Related Concepts

Computers, Digital
Diffusion
Noble Gases
Helium
Respiration

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