Dual tracer tau PET imaging reveals different molecular targets for 11 C-THK5351 and 11 C-PBB3 in the Alzheimer brain

European Journal of Nuclear Medicine and Molecular Imaging
Konstantinos ChiotisAgneta Nordberg

Abstract

Several tau PET tracers have been developed, but it remains unclear whether they bind to the same molecular target on the heterogeneous tau pathology. In this study we evaluated the binding of two chemically different tau-specific PET tracers (11C-THK5351 and 11C-PBB3) in a head-to-head, in vivo, multimodal design. Nine patients with a diagnosis of mild cognitive impairment or probable Alzheimer's disease and cerebrospinal fluid biomarker evidence supportive of the presence of Alzheimer's disease brain pathology were recruited after thorough clinical assessment. All patients underwent imaging with the tau-specific PET tracers 11C-THK5351 and 11C-PBB3 on the same day, as well as imaging with the amyloid-beta-specific tracer 11C-AZD2184, a T1-MRI sequence, and neuropsychological assessment. The load and regional distribution of binding differed between 11C-THK5351 and 11C-PBB3 with no statistically significant regional correlations observed between the tracers. The binding pattern of 11C-PBB3, but not that of 11C-THK5351, in the temporal lobe resembled that of 11C-AZD2184, with strong correlations detected between 11C-PBB3 and 11C-AZD2184 in the temporal and occipital lobes. Global cognition correlated more closely with 11C-THK53...Continue Reading

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Citations

Mar 29, 2019·European Journal of Nuclear Medicine and Molecular Imaging·N Arul MuruganAgneta Nordberg
Jun 7, 2019·Current Neurology and Neuroscience Reports·Yi Ting Wang, Paul Edison
Jan 13, 2019·Molecular Psychiatry·Antoine LeuzyAgneta Nordberg
May 30, 2019·Journal of Neurology·Tatsuhiro TeradaYasuomi Ouchi
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Sep 25, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Mona-Lisa MalarteLaetitia Lemoine
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Apr 23, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Leonie BeyerMatthias Brendel
Jan 9, 2021·Brain and Cognition·Lou RizzoloFabienne Collette
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Apr 28, 2021·Molecular Neurodegeneration·Tatsuhiro TeradaPedro Rosa-Neto
May 6, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Carla PalleisGünter U Höglinger

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Methods Mentioned

BETA
ELISAs

Software Mentioned

R
FreeSurfer
SPM12

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