Duality of innate stress responses in cardiac injury, repair, and remodeling

Journal of Molecular and Cellular Cardiology
Eric M WilsonDouglas L Mann

Abstract

The ability of the myocardium to successfully adapt to cardiac injury ultimately determines whether the heart will decompensate and fail, or whether instead it will maintain preserved function. Despite the importance of the myocardial response to cardiac injury, very little is known with respect to the biochemical mechanisms that are responsible for mediating and integrating the stress response in the heart. In the present review we will summarize recent experimental material which suggests that the heart possess a germ-line encoded "innate" stress response that is activated in response to diverse forms of tissue injury. The extant literature suggests that this innate stress response plays an important role in initiating and integrating homeostatic responses within the heart. Nonetheless, as will be discussed further herein, these inflammatory mediators all have the potential to produce cardiac decompensation when expressed at sufficiently high concentrations.

Citations

Feb 7, 2014·Cardiovascular Research·Alessandra GhigoEmilio Hirsch
Jul 25, 2006·Infection and Immunity·Alaka MullickPhilippe Gros
Nov 19, 2008·Fibrogenesis & Tissue Repair·Jana S Burchfield, Stefanie Dimmeler
Dec 11, 2008·The Journal of Pharmacology and Experimental Therapeutics·Jianli NiuPappachan E Kolattukudy
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Adelaide M Arruda-OlsonVéronique L Roger
Jan 8, 2010·The Journal of Physiological Sciences : JPS·John C QuindryScott Powers
Sep 28, 2012·Journal of Cardiovascular Translational Research·Melissa L Martin, Burns C Blaxall
Feb 8, 2006·Annual Review of Physiology·Viviany R TaquetiAndrew H Lichtman
Mar 29, 2012·Current Heart Failure Reports·Thor UelandPål Aukrust
Aug 29, 2013·Heart & Lung : the Journal of Critical Care·Brent A Williams, Michael E Merhige
Aug 29, 2012·Trends in Cardiovascular Medicine·Daniela Carnevale, Giuseppe Lembo
Oct 29, 2011·Mayo Clinic Proceedings·Adelaide M Arruda-OlsonSuzette J Bielinski
May 20, 2014·Pharmacology & Therapeutics·Joost P G SluijterUNKNOWN Nucleus of the European Society of Cardiology Working Group Cellular Biology of the Heart
Jul 2, 2009·Clinical Science·Jianli Niu, Pappachan E Kolattukudy
Jul 20, 2006·Expert Opinion on Therapeutic Targets·Noriyuki OuchiKenneth Walsh
Feb 10, 2012·Toxicology and Industrial Health·Samiha M Abd El-DayemBosy A Abd El Motelp
Jun 6, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Volker AdamsGerhard Schuler
Sep 9, 2017·Exercise and Sport Sciences Reviews·John C Quindry, Barry A Franklin
Jun 21, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·John C Quindry
Feb 14, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Tomomi MohriJunichi Azuma
May 2, 2007·Current Cardiology Reports·Arne YndestadPål Aukrust
Feb 3, 2018·International Journal of Molecular Medicine·Jia LiuJun Cai
Dec 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Laurel A GrisantiDouglas G Tilley
Feb 23, 2021·Signal Transduction and Targeted Therapy·Kang SunJin Jin
Mar 7, 2021·The American Journal of Cardiology·John C Quindry, Barry A Franklin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis