PMID: 11929208Apr 4, 2002Paper

Duchenne muscular dystrophy

The Journal of the American Academy of Orthopaedic Surgeons
M D Sussman

Abstract

Duchenne muscular dystrophy is an X-linked disease of muscle caused by an absence of the protein dystrophin. Affected boys begin manifesting signs of disease early in life, cease walking at the beginning of the second decade, and usually die by age 20 years. Until treatment of the basic genetic defect is available, medical, surgical, and rehabilitative approaches can be used to maintain patient function and comfort. Corticosteroids, including prednisone and a related compound, deflazacort, have recently been shown to markedly delay the loss of muscle strength and function in boys with Duchenne muscular dystrophy. Surgical release of lower extremity contractures may benefit some patients. Approximately 90% of boys with Duchenne muscular dystrophy will develop severe scoliosis, which is not amenable to control by nonsurgical means such as bracing or adaptive seating. The most effective treatment for severe scoliosis is prevention by intervening with early spinal fusion utilizing segmental instrumentation as soon as curves are ascertained and before the onset of severe pulmonary or cardiac dysfunction.

References

Sep 1, 1992·Developmental Medicine and Child Neurology·F MillerJ Koreska
Mar 1, 1992·The Journal of Bone and Joint Surgery. British Volume·C S GalaskoP Morris
Sep 6, 1986·Lancet·S KhodadadehG A Evans
Jul 7, 1988·The New England Journal of Medicine·R J BarohnJ R Mendell
May 1, 1986·The Journal of Bone and Joint Surgery. British Volume·L Read, C S Galasko
Sep 28, 1995·The New England Journal of Medicine·J R MendellR Rice
Feb 1, 1995·The Journal of Cell Biology·C PasternakE L Elson
Nov 1, 1993·Journal of Pediatric Orthopedics·S J MubarakJ Leach
Jun 1, 1993·Journal of Medical Genetics·A E Emery, M L Emery
Dec 1, 1996·The Journal of Bone and Joint Surgery. American Volume·P J VignosB Katirji
Feb 27, 1997·The New England Journal of Medicine·D J DugganC Angelini
Oct 23, 1997·Current Opinion in Neurology·G KarpatiJ Nalbantoglu
Jul 14, 1998·Seminars in Pediatric Neurology·R J PolakoffC M Rios
Dec 30, 1998·Irish Journal of Medical Science·J J RiceF McManus
Jun 26, 1999·Neuromuscular Disorders : NMD·J Forst, R Forst
Jul 8, 1999·Molecular and Cellular Biochemistry·J P Infante, V A Huszagh
Aug 17, 1999·The Journal of Clinical Investigation·E R Barton-DavisH L Sweeney
Aug 27, 1999·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·V Jay
Oct 26, 1999·The Journal of Bone and Joint Surgery. British Volume·B A Alman, H K Kim
Jan 10, 2001·The Journal of Pediatrics·W D BiggarC A Steele
Jan 22, 2002·Neuromuscular Disorders : NMD·B TalimL Merlini

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Citations

Jan 2, 2007·Clinical Orthopaedics and Related Research·Odette LaneuvilleGuy Trudel
May 21, 2009·Developmental Medicine and Child Neurology·Carole VuillerotCarole Berard
Jul 1, 2010·Journal of Child Neurology·Susan Sienko ThomasMichael D Sussman
Jan 1, 2009·Revista Brasileira De Ortopedia·Cláudio SantiliMiguel Akkari
Jul 28, 2016·Frontiers in Cellular Neuroscience·Ruben G F HendriksenJohan S H Vles
Oct 27, 2016·The Journal of Biological Chemistry·Shu-Ching HuangEdward J Benz
Sep 8, 2020·Muscle & Nerve·Hasan DemirciHasmet Hanagasi
Jan 23, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Lineu C WerneckRosana H Scola
Apr 11, 2017·Journal of Child Neurology·Rebecca LatimerUNKNOWN Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STAR net)
Apr 3, 2009·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·F Canavese, M D Sussman
Oct 30, 2012·Journal of Muscle Research and Cell Motility·Jong-Hee KimJohn M Lawler
Feb 26, 2015·Journal of Pediatric Orthopedics. Part B·Lee S SegalM Wade Shrader
May 7, 2016·Prosthetics and Orthotics International·Céline DelvertCarole Vuillerot
Dec 13, 2017·Oncotarget·Musarrat Maisha RezaCraig McFarlane
May 8, 2018·American Journal of Physical Medicine & Rehabilitation·Abhinandan BatraKrista Vandenborne
Sep 2, 2020·Connective Tissue Research·Claire YuanRobert W Grange
Nov 26, 2010·Muscle & Nerve·Jennifer E Stevens-LapsleyMatthew Taylor
Feb 2, 2018·Postgraduate Medical Journal·Vassili Crispi, Antonios Matsakas
Feb 6, 2020·Arquivos de neuro-psiquiatria·Thiago Henrique da SilvaFátima Aparecida Caromano
Oct 26, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christian IsaacJohnny Huard
Feb 16, 2018·Frontiers in Human Neuroscience·Marije GoudriaanKaat Desloovere
Feb 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Lori A Karol
May 17, 2011·The Veterinary Record·Ken Smith
Mar 11, 2016·The American Journal of Pathology·Mutsuki KuraokaShin'ichi Takeda
Jul 6, 2010·Archives of Physical Medicine and Rehabilitation·Sunita MathurKrista Vandenborne
Apr 7, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Eunyoung Choi, Taeyoung Koo
Jun 12, 2008·Journal of Orthopaedic Surgery and Research·Hitesh N ModiJae-Hyuk Yang
Nov 26, 2009·Neuromuscular Disorders : NMD·Anthony P MarshMartin K Childers
Dec 4, 2019·Neuromuscular Disorders : NMD·Alberto RomanoGessica Vasco

❮ Previous
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