Duck PIAS2 negatively regulates RIG-I mediated IFN-β production by interacting with IRF7.

Developmental and Comparative Immunology
Shaopo ZuMing Liao

Abstract

The protein inhibitor of activated STAT (PIAS) proteins are important signal transduction modulator family and regulate the innate immune signaling pathway induced by certain transcription factors, including NF-κB, IRF3, and JAK/STAT. The PIAS protein mechanism that regulates innate immune response in mammals has been well described in the literature; however, whether the PIAS gene exists in ducks as well as the role of PIAS in duck IFN-β expression is still unclear. Here, we cloned duck PIAS (duPIAS), finding PIAS2 could repress IFN-β production. DuPIAS2 contains SAP-PINIT-RLD-S/T characteristic domains, and its overexpression could inhibit virus-induced IFN-β promoter activation. Moreover, duPIAS2 interacts with duck interferon regulatory factor 7 (IRF7) and inhibits IFN-β promoter activation induced by duck IRF7. Additionally, its inhibitory function does not rely on its SUMO E3 ligase activity but rather its C-terminal portion. The above results demonstrate that duPIAS2 is a repressor of IFN-β production induced by duck IRF7.

References

Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·B LiuK Shuai
Oct 5, 2001·Molecular Cell·T KahyoH Yasuda
Jan 15, 2002·The Journal of Biological Chemistry·Tamar MegidishC Wilson Xu
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Darja Schmidt, Stefan Müller
May 14, 2004·The Journal of Biological Chemistry·Hyun Duk JangSoo Young Lee
Aug 2, 2005·Nature Reviews. Immunology·Ke Shuai, Bin Liu
Jan 21, 2006·Nature Immunology·Taro Kawai, Shizuo Akira
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Nov 10, 2007·Journal of Molecular Biology·Elena TolkunovaAlexey Tomilin
Jan 6, 2009·Immunological Reviews·Mitsutoshi Yoneyama, Takashi Fujita
Jan 6, 2009·Immunological Reviews·Osamu Takeuchi, Shizuo Akira
Jan 12, 2010·Current Opinion in Immunology·Anne F McGettrick, Luke A J O'Neill
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Jaclyn R Gareau, Christopher D Lima
Jan 5, 2011·The Journal of Biological Chemistry·Toru KubotaKeiko Ozato
Jan 20, 2012·Journal of Virology·Søren Jensen, Allan Randrup Thomsen
Feb 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ran XiongJian-zhong Shao
Dec 12, 2012·Molecular Immunology·Megan R W BarberKatharine E Magor
May 29, 2013·Cytokine & Growth Factor Reviews·Paul J Hertzog, Bryan R G Williams
Mar 25, 2014·Annual Review of Immunology·Jiaxi Wu, Zhijian J Chen
Aug 2, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuqiang ChengJianhe Sun
Nov 24, 2019·Developmental and Comparative Immunology·Xianan FuShengfeng Huang

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Citations

Jul 9, 2021·Molecular Psychiatry·Joana MagalhaesShohreh Issazadeh-Navikas
Jul 20, 2021·Current Opinion in Oncology·Li DuSteven T Rosen

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