Duct-to-mucosa versus invagination pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis

Oncotarget
Shuisheng ZhangXiaozhun Huang

Abstract

We aimed to compare the two most commonly used pancreatico-jejunostomy reconstruction techniques-duct-to-mucosa and invagination. Databases, including MEDLINE, EMBASE, Cochrane Library, and several clinical trial registration centers were searched. Randomized controlled trials that compared duct-to-mucosa and invagination pancreaticojejunostomy techniques after pancreaticoduodenectomy were included and analyzed. In total, seven RCTs were included, involving 850 patients. The difference in postoperative pancreatic fistula rate between the duct-to-mucosa and invagination pancreaticojejunostomy was not significant (RR = 1.03, 95% CI = 0.76-1.39, P = 0.86). There was no significant difference in clinically relevant postoperative pancreatic fistula between the two groups (RR = 0.78, 95% CI = 0.15-3.96, P = 0.77). The overall morbidity, overall mortality, delayed gastric emptying, intra-abdominal collection, reoperation rate, and length of hospital stay between the two groups were not significantly different. Sensitivity analysis showed that the meta-analysis was stable. Further, no significant publication bias was seen. Duct-to-mucosa and invagination pancreaticojejunostomy techniques after pancreaticoduodenectomy were comparable in...Continue Reading

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Citations

Jul 10, 2019·Expert Review of Gastroenterology & Hepatology·Yien XiangXuewen Zhang
Aug 11, 2021·Surgery·Ekaterina PetrovaUNKNOWN Dutch Pancreatic Cancer Group and DGAV StuDoQ|Pancreas
Feb 6, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Lyonell B KoneAjay V Maker

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