Ductal carcinoma in situ of the breast: immune cell composition according to subtype.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Marie Colombe AgahozoCarolien H M van Deurzen

Abstract

Ductal carcinoma in situ of the breast includes several subtypes with a divergent biological behavior. Data regarding the composition of ductal carcinoma in situ-associated immune cells and their potential role in progression is limited. We studied ductal carcinoma in situ-associated immune response by characterizing immune cell subsets according to ductal carcinoma in situ subtypes. Ductal carcinoma in situ-associated tumor infiltrating lymphocyte (TIL) density was evaluated based on hematoxylin and eosin (H&E)-stained sections from 473 patients. Cases were subtyped based on ER, PR, and HER2. Patients were categorized as TIL-high or low. Ductal carcinoma in situ-associated immune cells of TIL-high cases were immunostained on whole slides with CD4, CD8, CD20, CD68, FOXP3, and PD-L1 (SP142 and SP263). In total, 131/473 patients (28.0%) were considered as TIL-high. The percentage of TIL-high cases was significantly higher in HER2+ and triple-negative ductal carcinoma in situ (P < 0.0001). Overall, no statistical difference in immune cell composition according to subtypes was found. However, individual subtype comparison showed that ER+ HER2+ cases had a significantly higher proportion of CD8+ T cells compared with triple-negative...Continue Reading

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Citations

Apr 29, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marie Colombe AgahozoCarolien H M van Deurzen
Jul 18, 2021·The Breast : Official Journal of the European Society of Mastology·Rafael CaparicaEvandro de Azambuja

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