Ductal closure with intravenous paracetamol: a new approach to patent ductus arteriosus treatment

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Asli MemisogluEren Ozek

Abstract

Indomethacin and ibuprofen are commonly used in the treatment of hemodynamically significant patent ductus arteriosus (hsPDA). These drugs are associated with serious adverse events, including gastrointestinal perforation, renal failure and bleeding. The role of paracetamol has been proposed for the treatment of PDA. We report a series of 11 neonates (birth weight: 415-1580 g; gestational age: 23-30.3 weeks) who were treated with paracetamol for a hsPDA. Neonates with hsPDA were treated with paracetamol in the presence of contraindications to ibuprofen or indomethacin. The condition of significant PDA was defined by the presence of at least one of the following criteria: internal ductal diameter # 1.4 mm/kg body weight, left atrium (LA)-to-aortic (Ao) root ratio > 1.4, unrestrictive pulsatile transductal flow, reverse or absent diastolic flow in the descending aorta along with clinical findings. Intravenous (IV) paracetamol was given at doses 15 mg/kg every 6 h for three days. Successful ductal closure was achieved in 10 out of 11 babies (90.9%). No adverse or side effects were observed during the treatment. On the basis of these results, paracetamol could be considered as a promising and safe therapy for the treatment of PDA i...Continue Reading

References

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Citations

May 6, 2016·European Journal of Pediatrics·Enrico ValerioPaola Lago
Mar 23, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·L A DowdN J Medlicott
Jan 2, 2018·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Caitlyn M LueckeChristopher McPherson
Jun 26, 2018·Expert Opinion on Drug Metabolism & Toxicology·Laura CuzzolinVassilios Fanos
Aug 23, 2017·BioMed Research International·Flaminia BardanzelluVassilios Fanos
Nov 1, 2015·Pain and Therapy·Maurizio de Martino, Alberto Chiarugi
Mar 2, 2018·Frontiers in Pediatrics·Ines TofeJuan Luis Perez-Navero
Feb 28, 2021·Journal of Clinical Pharmacy and Therapeutics·Kannan SridharanAbdulraoof Al Madhoob
Feb 23, 2021·The Journal of Pediatrics·Clyde J Wright

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