Ductile electroactive biodegradable hyperbranched polylactide copolymers enhancing myoblast differentiation

Biomaterials
Meihua XiePeter X Ma

Abstract

Myotube formation is crucial to restoring muscular functions, and biomaterials that enhance the myoblast differentiation into myotubes are highly desirable for muscular repair. Here, we report the synthesis of electroactive, ductile, and degradable copolymers and their application in enhancing the differentiation of myoblasts to myotubes. A hyperbranched ductile polylactide (HPLA) was synthesized and then copolymerized with aniline tetramer (AT) to produce a series of electroactive, ductile and degradable copolymers (HPLAAT). The HPLA and HPLAAT showed excellent ductility with strain to failure from 158.9% to 42.7% and modulus from 265.2 to 758.2 MPa. The high electroactivity of the HPLAAT was confirmed by UV spectrometer and cyclic voltammogram measurements. These HPLAAT polymers also showed improved thermal stability and controlled biodegradation rate compared to HPLA. Importantly, when applying these polymers for myotube formation, the HPLAAT significantly improved the proliferation of C2C12 myoblasts in vitro compared to HPLA. Furthermore, these polymers greatly promoted myogenic differentiation of C2C12 cells as measured by quantitative analysis of myotube number, length, diameter, maturation index, and gene expression of ...Continue Reading

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Citations

Oct 1, 2016·Scientific Reports·Cancan XuYi Hong
Apr 29, 2016·Journal of Biomedical Materials Research. Part a·Cancan XuYi Hong
Nov 1, 2018·Frontiers of Medicine·Bo LeiPeter X Ma
Jun 29, 2016·Scientific Reports·Archana BettadapurMegan L McCain
Jan 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Longchao LiBaolin Guo
Aug 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xian Li, Xiulan Su
Dec 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·J K PonniahJ G Jacot
Aug 22, 2018·Advanced Functional Materials·Dingying ShanJian Yang
Apr 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ChenPeter X Ma
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Kwang-Hwan ChoiChang-Kyu Lee
Apr 4, 2021·International Journal of Molecular Sciences·Reza ZeinaliJordi Puiggalí
Jun 3, 2021·International Journal of Molecular Sciences·Emine AlarcinMeltem Avci-Adali
Jun 26, 2021·International Journal of Biological Macromolecules·Syed Ahmed ShahMehboob Ur Rehman Kashif
Aug 3, 2021·Acta Biomaterialia·Eleana ManousiouthakisChristine E Schmidt
Aug 28, 2021·International Journal of Molecular Sciences·Arsalan Ul HaqPaolo Di Nardo

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