Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean.

British Journal of Haematology
Victor R GrannDawn L Hershman

Abstract

Neutropenia associated with race/ethnicity has essentially been unexplained and, although thought to be benign, may affect therapy for cancer or other illnesses. A recent study linked a single nucleotide polymorphism (SNP) (rs2814778) in the Duffy antigen/receptor chemokine gene (DARC) with white blood cell count. We therefore analysed the association of the rs2814778 CC, TC and TT genotypes with absolute neutrophil count (ANC) among asymptomatic women from the Caribbean, Europe and the United States. Among 261 study participants, 33/47 women from Barbados/Trinidad-Tobago, 34/49 from Haiti, 26/37 from Jamaica, and 29/38 US-born black women, but only 4/50 from the Dominican Republic and 0/40 US- or European-born whites (P = 0.0001) had the CC genotype. In a linear regression model that included percentage African ancestry, national origin, cytokines, socio-economic factors and the ELA2 rs57834246 SNP, only the DARC rs2814778 genotype and C-reactive protein were associated with ANC (P < 0.0001). Women with the CC genotype had lower ANC than other women. Further research is needed on the associations of rs2814778 genotype with neutropenia and treatment delay in the setting of cancer. A better understanding of these associations ma...Continue Reading

References

Aug 5, 1976·The New England Journal of Medicine·L H MillerM H McGinniss
Jun 29, 1999·The Journal of Laboratory and Clinical Medicine·T B HaddyO Castro
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Martin H SteinbergMichael Terrin
Oct 16, 2003·Journal of the National Cancer Institute·Dawn HershmanAlfred I Neugut
Feb 16, 2005·Genetic Epidemiology·Hua TangNeil J Risch
Oct 21, 2006·Blood·Marshall S HorwitzStephen J Salipante
Dec 7, 2006·Nucleic Acids Research·Donna MaglottTatiana Tatusova
Mar 29, 2007·Human Genetics·Christina L Wassel FyrUNKNOWN Health, Aging, Body Composition Study
Apr 4, 2007·Annals of Internal Medicine·Matthew M HsiehGriffin P Rodgers
Jun 11, 2008·Cancer·Victor R GrannDawn L Hershman

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Citations

Dec 15, 2010·Immunology and Cell Biology·Chris A H HansellRobert J B Nibbs
Apr 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Veron RamsuranThumbi Ndung'u
Sep 3, 2011·Southern Medical Journal·Alva B WeirRafael Arteta-Bulos
May 21, 2011·Orphanet Journal of Rare Diseases·Jean DonadieuChristine Bellanné Chantelot
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew M HsiehRichard F Little
Apr 3, 2013·Pediatrics in Review·Kelly Walkovich, Laurence A Boxer
Jan 29, 2013·Hematology/oncology Clinics of North America·Jean DonadieuChristine Bellanné-Chantelot
Jan 29, 2013·Hematology/oncology Clinics of North America·Marshall S HorwitzTimothy Tidwell
Feb 12, 2009·British Journal of Haematology·Araba Afenyi-AnnanMarilyn J Telen
Nov 18, 2009·American Journal of Physical Anthropology·Tanya M SimmsRene J Herrera
May 24, 2016·BMC Hematology·Srdjan DenicAbdul-Kader Souid
Sep 7, 2017·British Journal of Haematology·Jean DonadieuChristine Bellanné-Chantelot
Dec 10, 2013·Nature Reviews. Immunology·Robert J B Nibbs, Gerard J Graham
Aug 28, 2014·The Pediatric Infectious Disease Journal·Zhou ShuXiao-Dong Zhao
Nov 22, 2013·Current Opinion in Hematology·Christina F Thobakgale, Thumbi Ndung'u
Apr 7, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ritesh GoswamiM Joseph John
Jun 9, 2017·Nature Reviews. Disease Primers·Julia SkokowaKarl Welte
Nov 9, 2019·Scientific Reports·T R L KleiR van Bruggen

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Methods Mentioned

BETA
genotyping

Software Mentioned

MassARRAY

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