Duloxetine and Angiotensin II Receptor Blocker Combination Potentially Induce Severe Hyponatremia in an Elderly Woman

Internal Medicine
Atsushi TakayamaMasaru Nakamura

Abstract

We encountered a case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) caused by duloxetine, serotonin and norepinephrine reuptake inhibitor (SNRI). A 74-year-old woman complaining of severe lethargy was transferred to our emergency department. Her serum sodium level was 109 mEq/L. Plasma hypo-osmolality with urine normo-osmolality was observed, indicating SIADH. Her essential hypertension had long been treated with telmisartan, and she had just started duloxetine 20 mg/day for chronic musculoskeletal pain 4 days prior to admission. On prescribing duloxetine in the primary care setting, clinicians should be aware of the possibility of duloxetine-induced hyponatremia, particularly in combination with telmisartan.

References

Apr 1, 1996·Journal of the American Geriatrics Society·M MillerJ M Carter
Sep 23, 2000·The New England Journal of Medicine·A I Arieff, J C Ayus
May 29, 2001·International Journal of Geriatric Psychiatry·D Kirby, D Ames
Nov 1, 2005·Expert Opinion on Drug Safety·Joachim F WernickeLars Viktrup
Jan 30, 2007·Current Medical Research and Opinion·James GahimerLars Viktrup
Feb 29, 2008·Harvard Review of Psychiatry·Arthur J Siegel
Aug 7, 2009·Fundamental & Clinical Pharmacology·Claudia R FelipeJose O Medina-Pestana
Mar 4, 2011·Clinical Pharmacokinetics·Mary Pat KnadlerRichard Bergstrom
Jun 17, 2011·Nephron. Clinical Practice·Pasquale EspositoAntonio Dal Canton
Jul 7, 2012·Therapeutics and Clinical Risk Management·Howard S SmithBenjamin R Smith
Aug 16, 2013·Electrolyte & Blood Pressure : E & BP·Biff F Palmer
May 2, 2014·European Journal of Clinical Nutrition·P EspositoA Dal Canton
Sep 14, 2014·Archives of Gerontology and Geriatrics·Lurdes CorreiaNascimento Costa
Jul 23, 2015·Indian Journal of Nephrology·M Kulkarni
Apr 21, 2016·Journal of Endocrinological Investigation·M CuestaC J Thompson
Oct 22, 2016·American Journal of Physiology. Renal Physiology·Yang GaoDonald E Kohan

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