Duloxetine in the treatment of major psychiatric and neuropathic disorders

Expert Review of Neurotherapeutics
Norbert MüllerHans-Jürgen Möller

Abstract

Major depressive disorder (MDD) is one of the most disabling disorders. Antidepressant pharmacotherapy is currently effective in approximately 70% of all treated cases; the potential superiority of a dual mechanism of pharmacological action (e.g., inhibiting the reuptake of serotonin and norepinephrine) is widely known. Duloxetine, a novel dual acting, selective serotonin and norepinephrine reuptake inhibitor, has demonstrated clinical efficacy in the treatment of MDD and general anxiety disorder (GAD). Duloxetine has been found to be safe and well tolerated, with mild-to-moderate adverse events, a favorable cardiovascular and sexual dysfunction profile, and minor influence on weight gain. The efficacy of duloxetine in the treatment of MDD has been established in randomized, double-blind, placebo-controlled studies. In addition to improving classical emotional symptoms of MDD, duloxetine has in particular beneficial effects on somatic symptoms of depression including pain. The superiority of duloxetine was shown over placebo, while comparison studies with other antidepressants showed only partial superiority. Randomized clinical trials in GAD also provide evidence for beneficial effects compared with placebo and improvement in ...Continue Reading

References

Oct 1, 1988·Journal of Clinical Psychopharmacology·E J GarlandA P Zis
Jan 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D T WongD W Robertson
Apr 16, 1998·European Journal of Pharmacology·M TatsumiE Richelson
Oct 7, 1998·Acta Psychiatrica Scandinavica·M Posse, T Hällström
Feb 6, 1999·Journal of Clinical Psychopharmacology·R C RosenM Menza
Mar 31, 1999·The Behavioral and Brain Sciences·T J Coderre, J Katz
Oct 28, 1999·The New England Journal of Medicine·G E SimonJ Ormel
Feb 9, 2000·Journal of Clinical Pharmacology·A SharmaB J Cerimele
Jun 1, 2000·The Journal of Clinical Psychiatry·R M HirschfeldM Bourgeois
Jan 3, 2001·Harvard Review of Psychiatry·M MogotsiD J Stein
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F P BymasterD T Wong
Apr 3, 2002·The Journal of Clinical Psychiatry·David J GoldsteinMark A Demitrack
May 10, 2002·The Journal of Clinical Psychiatry·Michael J DetkeMark A Demitrack
May 22, 2002·The Journal of Clinical Psychiatry·Stephen M Stahl
Jul 13, 2002·American Journal of Obstetrics and Gynecology·Peggy A NortonUNKNOWN Duloxetine Urinary Incontinence Study Group
Oct 24, 2002·Journal of Psychiatric Research·Michael J DetkeMark A Demitrack
Aug 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·R J LantzM P Knadler
Sep 23, 2003·The Journal of Urology·Roger R DmochowskiUNKNOWN Duloxetine Urinary Incontinence Study Group
Nov 12, 2003·Archives of Internal Medicine·Matthew J BairKurt Kroenke
Nov 25, 2003·American Journal of Obstetrics and Gynecology·Nancy H FultzRichard C Bump
Dec 9, 2003·The Journal of Clinical Psychiatry·Joel RaskinMargaret B Ferguson
Feb 7, 2004·BJU International·R J MillardUNKNOWN Duloxetine UI Study Group
Feb 14, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Philip van KerrebroeckUNKNOWN Duloxetine Urinary Incontinence Study Group
Jul 3, 2004·Journal of Clinical Psychopharmacology·David J GoldsteinMark A Demitrack
Jul 10, 2004·Journal of General Internal Medicine·Teri GrecoKurt Kroenke
Aug 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C DaousiS J Benbow
Sep 2, 2004·Obstetrics and Gynecology·Linda CardozoRichard C Bump
Oct 27, 2004·Journal of Psychiatric Research·Stephen K BrannanAlan F Schatzberg
Dec 14, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michael J DetkeIstvan Bitter
Jan 22, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Kraig S KinchenRalph Swindle
Mar 2, 2005·Journal of Clinical Psychopharmacology·Michael E ThaseMichael J Detke
Apr 12, 2005·The Journal of Urology·Gamal M GhoniemUNKNOWN Duloxetine/Pelvic Floor Muscle Training Clinical Trial Group
Jun 2, 2005·Pain·David J GoldsteinSmriti Iyengar

❮ Previous
Next ❯

Citations

Oct 17, 2009·Journal de la Société de biologie·Bernard Scatton
Dec 22, 2010·European Child & Adolescent Psychiatry·Lidewij M E KnookElisabeth R de Graeff-Meeder
May 24, 2012·Brain Research·Jin-Sung Choi, Sang June Hahn
Mar 27, 2015·PloS One·Marco RedaelliCarla Mucignat-Caretta
Sep 9, 2015·International Journal of Psychiatry in Medicine·Murielle GirardDominique Malauzat
Jan 1, 2012·International Journal of Immunopathology and Pharmacology·M RanieriM Megna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.