Duodenal- jejunal bypass sleeve: a totally endoscopic device for the treatment of morbid obesity

Surgical Innovation
K GersinB Todd Heniford

Abstract

Morbid obesity affects over 15 million people in the United States. Nonsurgical management produces sustained weight loss in less than 5% of patients. Despite associated comorbidities, less than 1% of obese patients seek surgical intervention. Less invasive procedures have been developed with varying success. The Endobarrier( trade mark) (GI Dynamics(trade mark), Watertown, MA) duodenal-jejunal bypass sleeve is a totally endoscopically delivered device designed to produce weight loss in the morbidly obese. We describe the first placement of a duodenal-jejunal bypass sleeve in a patient in the United States. A blinded, randomized, prospective clinical trial was approved by the Food and Drug Administration to evaluate safety and efficacy of a novel device for weight loss in the obese. The first patient enrolled was a 36-year-old woman with body mass index of 45.2. After informed consent, endoscopic placement of the device under general anesthesia was performed using fluoroscopy to confirm positioning. The device was placed without complications. At conclusion of the 3-month study period, the device was removed endoscopically. Total weight lost by the patient was 9.09 kg. Described herein is the first deployment of the duodenal-je...Continue Reading

References

Feb 22, 2002·The New England Journal of Medicine·Susan Z Yanovski, Jack A Yanovski
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Katherine M FlegalClifford L Johnson
Oct 15, 2003·Archives of Internal Medicine·Roland Sturm
Jun 17, 2004·JAMA : the Journal of the American Medical Association·Allison A HedleyKatherine M Flegal
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Feb 3, 2005·Obesity Research·Thomas A WaddenKirstin J Byrne
Jul 14, 2005·Health Affairs·William E EncinosaChi-Chang Chen
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Sep 9, 2006·Surgical Endoscopy·R GonzalezM M Murr
Apr 21, 2007·Journal of General Internal Medicine·Cheryl Sterling LynchSaid A Ibrahim
May 15, 2007·Gastroenterology·Katherine A Elder, Bruce M Wolfe
Jul 21, 2007·The American Journal of Gastroenterology·G Anton DeckerJames S Scolapio

❮ Previous
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Citations

Jun 25, 2008·Obesity Surgery·Atul K MadanKhurram A Khan
Mar 23, 2012·Obesity Surgery·N NguyenF Favretti
Nov 13, 2009·Diabetes Technology & Therapeutics·Leonardo RodriguezChristopher Sorli
Oct 9, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Shashideep SinghalSury Anand
Sep 14, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rodrigo MuñozLee M Kaplan
Nov 24, 2011·World Journal of Gastroenterology : WJG·Chen HuangZheng-Jun Qiu
Oct 30, 2012·Clinical Medicine : Journal of the Royal College of Physicians of London·Keng Ngee Hng, Yeng S Ang
May 8, 2009·World Journal of Surgery·John B Dixon
Apr 3, 2010·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·R A Weiner
Mar 26, 2013·The Journal of Surgical Research·Andrew J BatchelderAchal Khanna
Jan 21, 2012·Cirugía española·José F NogueraGaspar Sanfeliu
Nov 8, 2011·The Surgical Clinics of North America·Sean M Lee, Aurora D Pryor
Apr 3, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Alex EscalonaLuis Ibáñez
Jul 28, 2009·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Michel GagnerRoss D Crosby
Jun 30, 2009·Gastrointestinal Endoscopy·Nicholas Stylopoulos, Vincent Aguirre
Jan 13, 2009·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Stacy A BrethauerUNKNOWN American Society for Metabolic and Bariatric Surgery Emerging Technologies Committee
Apr 28, 2009·Obesity·James C EllsmereLee M Kaplan
Jun 19, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Umberto MaggiRoberto Lauro
Feb 19, 2015·Obesity Surgery·Eduardo Guimarães Hourneaux de MouraCarlos Alberto Buchpiguel
Feb 24, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Richa VermaUNKNOWN ASMBS Emerging Technologies and Procedures Committee
Oct 16, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Stacy A BrethauerChristopher C Thompson
Mar 9, 2018·Endocrine Reviews·George A BrayThomas H Inge
May 3, 2014·Therapeutic Advances in Chronic Disease·Ji Chung ThamCarel W le Roux
Oct 14, 2014·World Journal of Gastroenterology : WJG·Farzin RashtiChristopher J Gostout
Dec 24, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Lynne L LevitskyAlison G Hoppin
Apr 18, 2020·Journal of Clinical Gastroenterology·Jessica J McMasterGerald J Holtmann
Feb 5, 2011·Postgraduate Medicine·Randall A Colucci
Aug 27, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Karl J NeffCarel le Roux
Jan 19, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Eduardo Espinet CollMiguel Muñoz-Navas
Aug 25, 2015·Journal of Clinical Gastroenterology·Deepanshu Jain, Shashideep Singhal
Mar 31, 2016·American Journal of Physiology. Endocrinology and Metabolism·Jill S CarmodyLee M Kaplan
Sep 5, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity

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