Duodenal alkaline secretion in rabbits: influence of artificial ventilation

Acta Physiologica Scandinavica
L HolmO Nylander

Abstract

The effect of artificial ventilation on duodenal alkaline secretion and blood flow was studied in sodium pentobarbital-anaesthetized rabbits. A duodenal segment (approximately 3 cm) was cannulated in situ and continuously perfused with isotonic saline, and the bicarbonate secretion was titrated by pH-stat. Compared with the spontaneous breathing state, artificial ventilation improved the respiratory status of the animal, increasing Po2 and decreasing both Pco2 and plasma bicarbonate. Duodenal blood flow as measured with laser-Doppler flowmetry was not altered but the alkaline secretion was reduced. Pretreatment with the alpha 2-adrenoceptor antagonist yohimbine (0.5 mg kg-1 i.v., followed by 0.5 mg kg-1 h-1 i.v.) or the ganglionic blocker hexamethonium (10 mg kg-1 i.v.) did not affect the decline in duodenal alkaline secretion in response to artificial ventilation. Nor did these pretreatments affect the changes in plasma bicarbonate and Pco2 or significantly alter the blood flow. Increasing Pco2 in the respirator air increased the plasma Pco2 and bicarbonate concentration as well as the duodenal bicarbonate secretion. Pretreatment with the carbonic anhydrase inhibitor acetazolamide (80 mg kg-1 i.v.) reduced the bicarbonate secr...Continue Reading

References

Sep 1, 1986·Acta Physiologica Scandinavica·C JönsonL Fändriks
Nov 1, 1987·Scandinavian Journal of Gastroenterology·K JohanssonO Lundgren
Jun 1, 1986·Acta Physiologica Scandinavica·C Jönson, L Fändriks
Jul 1, 1984·Medical & Biological Engineering & Computing·G E Nilsson
Jan 1, 1980·IEEE Transactions on Bio-medical Engineering·G E NilssonP A Obert
Dec 5, 1984·Biochimica Et Biophysica Acta·G A KuijpersS L Bonting

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Citations

Aug 4, 2005·Upsala Journal of Medical Sciences·Markus Sjöblom
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mari LeppilampiMarkus Sjöblom
Dec 1, 1993·Scandinavian Journal of Gastroenterology·M A AinsworthO B Schaffalitzky de Muckadell
Jun 29, 2011·Journal of Morphology·C G Farmer
Apr 15, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Johanna HenriksnäsLena Holm
Dec 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markus Sjöblom, Olof Nylander

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